The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics

Anesthesia Clinical Trial

Official title:

The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03588429
• Other study ID #: 2018CZTCWM
• Status: Completed
• Phase: Phase 3
• Start date: January 1, 2020
• Est. completion date: December 1, 2020

Study information

• Verified date: August 2018
• Source: Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and isoflurane at equi-minimum alveolar concentration using EEG analysis.

Description:

Anesthetic agents vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different spectral entropy or bispectral index values. However, there is no study that demonstrate the difference between analgesic potency of volatile anesthetics. The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and isoflurane at equi-minimum alveolar concentration using EEG analysis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. completion date: December 1, 2020
• Est. primary completion date: August 1, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years to 65 Years

Eligibility

Inclusion Criteria:

• patients undergoing general anesthesia using volatile anesthetics and intubation

• patients with american society of anesthesiologist physical status I, II

• patients obtaining written informed consent

Exclusion Criteria:

• patients with a history of any psychiatric or neurological disease

• patients who had received any medication affecting the central nervous system

• patients who had received medication affecting the sympathetic or parasympathetic nervous systems

• patients undergoing supraglottic airway for airway management

• pregnant women

Related Conditions & MeSH terms

• Anesthesia

Intervention

Drug:
• Sevoflurane
Anesthesia was maintained with sevoflurane in patients undergoing standardized nociceptive stimulus (long-lasting tetanic stimulus of the ulnar nerve; 30 s, 50 mA, 50 Hz, square-wave).
• Isoflurane
Anesthesia was maintained with isoflurane in patients undergoing standardized nociceptive stimulus (long-lasting tetanic stimulus of the ulnar nerve; 30 s, 50 mA, 50 Hz, square-wave).

Locations

Country	Name	City	State
China	Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine	Cangzhou	Hebei

Sponsors (1)

Lead Sponsor	Collaborator
Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	qCON index	The hypnotic potency of volatile anesthetics was evaluated by qCON index during standardized nociceptive stimulus (30 s, 50 mA, 50 Hz tetanic stimulation).	the 10 min at steady-state anesthesia after endotracheal intubation
Secondary	qNOX index	The analgesic potency of volatile anesthetics was evaluated by qNOX index during standardized nociceptive stimulus (30 s, 50 mA, 50 Hz tetanic stimulation).	the 10 min at steady-state anesthesia after endotracheal intubation