Hemodynamics for Equi-MAC Anesthesia

Anesthesia Clinical Trial

Official title:

Comparison of Vasodilative Effects Between Sevoflurane and Desflurane Using Peripheral Perfusion Index

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03570164
• Other study ID #: 2018-05-019
• Status: Completed
• Phase: N/A
• Start date: June 18, 2018
• Est. completion date: November 13, 2018

Study information

• Verified date: October 2019
• Source: Kangbuk Samsung Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to compare the peripheral perfusion index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent inhalation anesthesia.

Description:

Ether derivative anesthetics, including sevoflurane and desflurane, have direct activity on vascular tissue and both are vasodilators. However, there has been no direct comparison of vasodilative effect between sevoflurane and desflurane in vivo in humans. Peripheral perfusion index derived from photoplethysmographic waveform reflects peripheral vasomotor tone. Therefore, the purpose of this study is to compare the peripheral perfusion index values produced by sevoflurane and desflurane at equipotent concentration in patients undergoing single-agent inhalation anesthesia.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 70
• Est. completion date: November 13, 2018
• Est. primary completion date: November 13, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years to 65 Years

Eligibility

Inclusion Criteria:

• patients aged between 19 and 65 yr

• patients with American Society of Anesthesiologists physical status classification I or II

• patients scheduled for elective arthroscopic knee surgery under general anesthesia

• patients obtaining written informed consent

Exclusion Criteria:

• patients with a history of any disease associated with the autonomic nervous system

• patients receiving any medication affecting the sympathetic or parasympathetic nervous systems

• patients with cardiac arrhythmia, diabetes mellitus, and alcohol or drug abuse

• pregnant women

Related Conditions & MeSH terms

• Anesthesia

Intervention

Drug:
• Sevoflurane
End-tidal concentration of sevoflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.
• Desflurane
End-tidal concentration of desflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.

Locations

Country	Name	City	State
Korea, Republic of	Kangbuk Samsung Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Kangbuk Samsung Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	peripheral perfusion index	peripheral perfusion index value at a steady-state anesthesia of age-corrected 1.0 MAC	After a 30-min waiting period from the induction of anesthesia
Secondary	mean arterial pressure	mean arterial pressure at a steady-state anesthesia of age-corrected 1.0 MAC	After a 30-min waiting period from the induction of anesthesia
Secondary	heart rate	heart rate at a steady-state anesthesia of age-corrected 1.0 MAC	After a 30-min waiting period from the induction of anesthesia