Dexmedetomidine on Segmental EEG Power Spectra

Anesthesia Clinical Trial

Official title:

The Effects of Dexmedetomidine on Segmental EEG Power Spectra Activity Under Propofol-based Anesthesia

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03515876
• Other study ID #: 2018-52
• Status: Recruiting
• Start date: April 19, 2018
• Est. completion date: July 2019

Study information

• Verified date: April 2019
• Source: Sun Yat-sen University
• Contact: Zhi Wang, MD
• Phone: 13622740039
• Email: wwzz1898[@]163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To compare the EEG power spectra activity during propofol-based anesthesia in the presence or absence of dexmedetomidine in patients undergoing hysteroscopic examination and surgery to determine whether the addition of dexmedetomidine will induce better sleep-like anesthesia status.

Description:

Three groups of patients undergoing hysteroscopic examination and surgery will be studied: 1) control group, patients will receive propofol intravenous infusion to provide anesthesia; 2) dexmedetomidine 0.5 microgram/kg group. This dexmedetomidine dose is infused within 10 min and then the use of propofol for anesthesia; and 3) dexmedetomidine 1 microgram/kg group. This dexmedetomidine dose is infused within 10 min and then the use of propofol for anesthesia.

Each group will have 20 patients.

General conditions including blood pressure, respiration, and heart rates will be recorded.

EEG power spectra activity will be recorded no-invasively by a Narcotrend EEG monitor.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: July 2019
• Est. primary completion date: June 2019
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• American Society of Anesthesiologists Physical status I to II grade.

• body mass index 18 to 25 kg/m2

• no vision or hearing impairment

• will receive general anesthesia

Exclusion Criteria:

• with psychological or mental diseases

• with neurological diseases

• treating with steroids or with alcohol dependence.

Related Conditions & MeSH terms

• Anesthesia
• EEG Power Spectra

Locations

Country	Name	City	State
China	Sun Yat-Sen Memorial Hospital	Guangzhou	Guangdong

Sponsors (2)

Lead Sponsor	Collaborator
Zhiyi Zuo	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	EEG power spectra	EEG power spectra monitored no-invasively by Narcotrend	From prior to anesthesia to 10 min after anesthesia.
Secondary	Blood pressure	Blood pressure monitored no-invasively	From prior to anesthesia to 10 min after anesthesia.
Secondary	Respiration	Monitored no-invasively	From prior to anesthesia to 10 min after anesthesia.
Secondary	Heart rates	Monitored no-invasively	From prior to anesthesia to 10 min after anesthesia.