1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia

Anesthesia Clinical Trial

Official title:

1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03510013
• Other study ID #: HE601228
• Status: Completed
• Phase: N/A
• Start date: April 1, 2018
• Est. completion date: May 31, 2018

Study information

• Verified date: August 2018
• Source: Khon Kaen University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators propose a new wash-in technique for sevoflurane low flow anesthesia with fresh gas flow of O2:N2O or O2:air 1:1 L/min with sevoflurane 8%.

The objective of this study is to identify time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5%

Description:

The benefits of low flow anesthesia are economic, less pollution, more heat and humidity preservation but it requires appropriate wash-in phase. The current wash-in protocols for sevoflurane are complicated and time consuming. The investigators propose a new 1-1-8 sevoflurane wash-in protocol which is more simple and predictable.

The objective of this study is to identify time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5% with 1-1-8 wash-in protocol.

All patients will receive iv propofol 2 mg/kg as induction agent and succinyl choline 1.5 mg/kg for intubation. Then the ventilation will be controlled to achieve end-tidal CO2 30-35 mmHg with O2:N2O or O2:air 1:1 L/min with sevoflurane 8%. Time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5% will be recorded and analyzed. After that, the concentration of sevoflurane and anesthetic technique will be adjusted to requirement of anesthesiologist.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: May 31, 2018
• Est. primary completion date: May 31, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• ASA classification I-II

• age 18-65 years

Exclusion Criteria:

• BMI > 35

• contraindicated for N2O

• • with pulmonary or cardiac disease

Related Conditions & MeSH terms

• Anesthesia

Intervention

Procedure:
• 1-1-8 wash-in
wash-in phase during start of low flow anesthesia

Drug:
• Sevoflurane
Drug used for wash-in protocol

Locations

Country	Name	City	State
Thailand	Faculty of Medicine, Khon Kaen University	Khon Kaen

Sponsors (1)

Lead Sponsor	Collaborator
Khon Kaen University

Country where clinical trial is conducted

Thailand, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Time	Time (in second) to achieve alveolar concentration of sevoflurane 1, 1.5, 2, 2.5, 3, and 3.5%	participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes
Secondary	Heart rate	Heart rate (beat/min) at alveolar concentration of sevoflurane of 1, 1.5, 2, 2.5, 3 and 3.5%	participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes]
Secondary	Blood pressure	Blood pressure (systolic and diastolic (mmHg)) at alveolar concentration of sevoflurane of 1, 1.5, 2, 2.5, 3 and 3.5%	participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes]