The Effect of Propofol or Sevoflurane on Renal Function

Status Completed

Clinical Trial Summary

This study investigates the role of the anesthetic agents propofol and sevoflurane on renal function in otherwise healthy patients undergoing basic back surgery.

Clinical Trial Description

Water-sodium homeostasis is central for anyone undergoing surgery, and can therefore affect surgical outcome, level of postoperative care and the length of hospital stay. Too much or too little fluid during surgery can affect the patients negatively. The kidneys play an imperative role in the regulation of water and sodium homeostasis, however there are lack of knowledge in how the anesthesia per se affects renal function. Previous studies have shown that volatile anesthetic agents such as sevoflurane can cause fluid retention. Why this happens is not completely known. We are now investigating the different affects of sevoflurane and propofol anesthesia on renal function in patients undergoing basic back surgery to elucidate if there is a difference in the risk of developing acute kidney injury. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03336801
Study type	Interventional
Source	Uppsala University
Contact
Status	Completed
Phase	Phase 4
Start date	September 1, 2017
Completion date	January 10, 2020

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