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Determination of Propofol Target Concentration for Young and Elderly by Suppression Rate Analysis

Anesthesia Clinical Trial

Official title:
Determination of Propofol Target Concentration for Young and Elderly by Suppression Rate Analysis

Clinical Trial Summary

Propofol's dose-response curve is know for the average adult but propofol's plasmatic concentration under total intravenous anesthesia differences between young and elderly must be modeled. Adaptative clinical trial (Dixon's Up and Down) for determination of ED95% of propofol concentration for hypnosis under general anesthesia for young and elderly adults.

Clinical Trial Description

Propofol's dose-response curve is know for the average adult but propofol's plasmatic concentration under total intravenous anesthesia differences between young and elderly must be modeled. Method: adaptative clinical trial (Dixon's Up and Down method) for determination of ED95% of propofol concentration (plasmatic, Marsh model) for hypnosis (BIS ranging from 40 to 60) under general anesthesia for young and elderly adults. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03283410
Study type Interventional
Source Brasilia University Hospital
Contact
Status Withdrawn
Phase Phase 4
Start date January 30, 2017
Completion date January 30, 2017
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