Mini-fluid Challenge in Predicting Fluid Responsiveness During Prone Position Spine Surgery

Anesthesia Clinical Trial

Official title:

The Effectiveness of Mini-fluid Challenge in Predicting Fluid Responsiveness During Prone Position Spine Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03089710
• Other study ID #: 201612021RIND
• Status: Completed
• Phase: N/A
• Start date: March 31, 2017
• Est. completion date: September 14, 2018

Study information

• Verified date: October 2018
• Source: National Taiwan University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Perioperative fluid management is crucial for patients' outcome. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in prone position surgery.

Description:

Perioperative fluid management is crucial for patients' outcome. Series of studies have indicated that adequate fluid management optimizes the cardiac out put, improves tissue perfusion, thus decrease the risk of postoperative morbidity. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. To the best of our knowledge, the efficacy of the test was not discussed in the perioperative care in prone position surgery. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in prone position surgery.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: September 14, 2018
• Est. primary completion date: September 14, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria: meet both of

1. Patients receiving scheduled prone position spine surgery

2. BMI 18.5~30 kg.m-2

Exclusion Criteria:

1. age younger then 20 yrs or elder than 80 yrs

2. pregnant women

3. patients in intensive care units

4. patients with the underlying disease including respiratory failure(FEV1/FVC < 70 % and FEV1 < 50%), heart failure(NYHA score =III?IV), kidney failure(eGFR< 60 ml.min-1.1.73m-2), liver failure

5. patients with ongoing infection

6. patients allergic to voluven

Related Conditions & MeSH terms

• Anesthesia

Intervention

Other:
• Mini-fluid challenge
Mini-fluid challenge test with 100mL colloid infusion in 1 min

Locations

Country	Name	City	State
Taiwan	National Taiwan University	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	stroke volume variation(SVV)	interpretate the correlation of SVV and conventional fluid challenge	3hr
Other	plethysmographic variation index(PVI)	interpretate the correlation of PVI and conventional fluid challenge	3hr
Primary	Change of cardiac index after fluid loading	interpretate the correlation of mini-fluid challenge and conventional fluid challenge	3hr
Secondary	pulse pressure variation(PPV)	interpretate the correlation of PPV and conventional fluid challenge	3hr