Power Spectral Analysis of EEG During Equi-MAC Inhalation Anesthesia

Anesthesia Clinical Trial

Official title:

Power Spectral Analysis of the Electroencephalogram During Equi-MAC Sevoflurane vs. Desflurane Anesthesia: A Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02872389
• Other study ID #: KBSMC 2016-07-033
• Status: Completed
• Phase: Phase 3
• Start date: August 16, 2016
• Est. completion date: December 6, 2016

Study information

• Verified date: September 2020
• Source: Kangbuk Samsung Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this clinical trial is to compare hypnotic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using power spectral analysis of the electroencephalogram.

Description:

Volatile anesthetics vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different spectral entropy or bispectral index values. However, there were no studies that demonstrate the difference of hypnotic potency using power spectral analysis of electroencephalographic signals (e.g., spectral edge frequency 95%, total power, % value of each bandage). The purpose of this clinical trial is to compare hypnotic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using power spectral analysis of the electroencephalogram.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. completion date: December 6, 2016
• Est. primary completion date: December 6, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years to 65 Years

Eligibility

Inclusion Criteria:

• patients undergoing arthroscopic knee surgery under general anesthesia using volatile anesthetics

• patients with american society of anesthesiologist physical status I, II

• patients aged 19-65 years

• patients obtaining written informed consent

Exclusion Criteria:

• patients with a history of any psychiatric or neurological disease

• patients who had received any medication affecting the central nervous system

• patients who had received medication affecting the sympathetic or parasympathetic nervous systems

• patients undergoing tracheal intubation for airway management

• pregnant women

Related Conditions & MeSH terms

• Anesthesia

Intervention

Drug:
• Sevoflurane
Anesthesia was maintained with sevoflurane in patients undergoing arthroscopic knee surgery under general anesthesia. End-tidal concentration of sevoflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period.
• Desflurane
Anesthesia was maintained with desflurane in patients undergoing arthroscopic knee surgery under general anesthesia. End-tidal concentration of desflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period.

Locations

Country	Name	City	State
Korea, Republic of	Kangbuk Samsung Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Kangbuk Samsung Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Spectral edge frequency 95% value	EEG variables were measured after meeting steady-state anesthesia of 1 MAC.	During about 30 min study period
Secondary	Bispectral index	Bispectral index measurements were made after meeting steady-state anesthesia of 1 MAC.	During about 30 min study period