Intraoperative Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods.

Anesthesia Clinical Trial

— Lungbaro  

Official title:

Intraoperative Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02830516
• Other study ID #: LUA-74201
• Status: Completed
• Phase: N/A
• First received: June 21, 2016
• Last updated: January 5, 2018
• Start date: June 2016
• Est. completion date: December 31, 2016

Study information

• Verified date: January 2018
• Source: Sahlgrenska University Hospital, Sweden
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations i esophagus pressure divided by the tidal volume. This requires the presence of a esophageal balloon catheter which is cumbersome and costly. In this study values obtained as described above are compared to values obtained with a new method in which a stepwise increase in positive endexpiratory pressure (PEEP) is performed with a size which corresponds to the tidal volume which the patient is ventilated with. These measurements are performed in anesthetized patients prior to major surgery.

Description:

Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations in esophageal pressure divided by the tidal volume (Method 1). This requires the presence of a esophageal balloon catheter which is cumbersome and costly.

In this study values obtained as described in Method 1 above are compared to values obtained with a new method in which a PEEP-step is performed with a size which corresponds to the tidal volume which the patient is ventilated with. Measurements using Method 1 and 2 are performed in anesthetized patients prior to major surgery.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: December 31, 2016
• Est. primary completion date: December 31, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patient undergoing major surgery during anesthesia and muscle relaxation

Exclusion Criteria:

• Patient with chronic obstructive lung disease

Related Conditions & MeSH terms

• Anesthesia

Intervention

Other:
• Measurement of lung elastance by two methods
Measurement of tidal variations in esophageal pressure followed in the same patient by performing a PEEP-step while simultaneously measuring the change in lung volume

Locations

Country	Name	City	State
Sweden	Sahlgrenska University Hospital	Gothenburg

Sponsors (1)

Lead Sponsor	Collaborator
Stefan Lundin

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Measurement of lung elastance	Comparison of two method for measurements of lung elastance (Measurement of tidal variations in esophageal pressure followed in the same patient by performing a PEEP-step while simultaneously measuring the change in lung volume)	At 1 hour