Anesthesia Clinical Trial
Official title:
The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of Postoperative Nausea and Vomiting in the Women Patients Undergoing Thyroidectomy
The incidence of postoperative nausea and vomiting (PONV) after thyroidectomy have been shown
to be relatively high compared other surgeries, with a reported incidence 65-75 %. PONV may
increase patient discomfort, delay patient discharge, and increase the cost of patient care,
the risk of postoperative bleeding which may potentially cause airway obstruction.
It is reported that the maintenance of anesthesia with propofol-remifentanil or
sevoflurane-propofol-remifentanil decreased the incidence of PONV compared sevoflurane alone,
but failed to demonstrate the decreased incidence of PONV in 6-24 hr postoperative period in
patients undergoing thyroidectomy. Administration of Palonosetron, newly developed 5-HT3
antagonists with long half life (48 hrs) may decrease the incidence of PONV particularly
during this period.
The purpose of this study was to evaluate and compare the incidence of PONV after
thyroidectomy with three different anesthetic methods, sevoflurane or
sevoflurane-propofol-remifentanil or sevoflurane-propofol-remifentanil-palonosetron in woman
patients.
n/a
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