Anesthesia Clinical Trial
Official title:
Effect General and Regional Anesthesia on Glycocalyx
Observational study evaluating effect general or regional anaesthesia on glycocalyx by using perfused Boundary Region in sublingual microcirculation.
Study II: Effect general and regional anaesthesia on GCX Hypothesis to be tested: Regional
anaesthesia affects GCX less than general anaesthesia.
The aim of the study: Comparison of two anaesthesia techniques with respect to GCX.
Type of the study: Observational. Subjects: Adult patients ASA 2-3 undergoing elective total
knee replacement surgery under general or regional anaesthesia. Sample size calculation
(based on expected difference in PRB, alpha error I = 0,05 and study power = 0,99) = 52
patients. Investigators plan to enroll of 60 consecutive patients to reach 30 patients with
each type of anaesthesia. Intervention: none. Data to be recorded and analysed: Demographics,
ASA, physiologic functions (during surgery and 24 hours after surgery), fluids given,
sublingual microcirculation by SDF imaging will be recorded at time points: before
anaesthesia, 24 hours after anaesthesia, clinical outcome indicators, microcirculatory data
and Perfused Boundary Region.
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