Anesthesia Clinical Trial
Official title:
Cocaine Use and General Anesthesia: A Prospective Study of Cardiovascular and Anesthetic Effects
In this prospective study, investigators plan to evaluate the outcome of general anesthesia in the context of patients with a positive cocaine urine test. Patients with a positive urine cocaine test who do not appear acutely toxic and have normal vital signs may not have an increased rate of perioperative complications during elective surgery compared to similar patients with negative urine cocaine screening tests. Patients who are chronic cocaine users may have a higher anesthetic requirement.
Patients with a history of cocaine abuse who are scheduled to undergo surgery at Parkland
Hospital will be asked to provide a urine sample for a screening toxicology test on the day
of surgery. Patients will also be asked to fill out a questionnaire with questions pertaining
to their drug use history. The remaining aspects of perioperative care, including the general
anesthetic technique, will be standardized for all patients and will not differ from the
standard of care. The anesthesia faculty, resident, or CRNA will identify patients and obtain
consent and ask the patient to fill out the questionnaire. This prospective study is intended
to enroll about 300 cocaine positive and negative patients over a 2 year period.
Blood samples will be collected for analysis of cardiac troponin T (cTnT) pre- and
postoperatively.
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