Methohexital v Propofol as General Anesthetic in Patients on ACEIs or ARBs

Status Completed

Clinical Trial Summary

Patient undergoing general anesthesia in elective surgery will be assigned to receive either methohexital or propofol general anesthesia. Hypotensive events during the first 15 minutes of induction will be compared between the groups to ascertain which drug is less likely to cause a hypotensive event.

Clinical Trial Description

Patients taking angiotensin converting-enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) are susceptible to hypotensive events during general anesthesia. The purpose of this study is to determine if the use of either methohexital or propofol general anesthesias is more likely to result in hypotensive events in these patients during their induction. Hemodynamic metrics like blood pressure, mean arterial pressure, and heart rate will be monitored during the induction process, under both drugs, for use as the main metrics, as well as the need for vasopressors in response to patient hypotension. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02624050
Study type	Interventional
Source	Milton S. Hershey Medical Center
Contact
Status	Completed
Phase	N/A
Start date	August 1, 2016
Completion date	January 31, 2018

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