Anesthesia Clinical Trial
Official title:
The Effect of Pressure Support Ventilation on Minute Alveolar Ventilation and End-tidal Carbon Dioxide in Anesthetized Spontaneously Breathing Subjects
Verified date | January 2017 |
Source | Massachusetts General Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The aim of this prospective study is to determine the effect of pressure support ventilation (PSV) on minute alveolar ventilation (MAV) and end-tidal carbon dioxide (ETCO2) in anesthetized spontaneously breathing subjects by observing alterations of respiratory rate (RR), expiratory tidal volume, MAV and ETCO2 at variable levels of pressure support.
Status | Withdrawn |
Enrollment | 0 |
Est. completion date | March 2016 |
Est. primary completion date | March 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility |
Inclusion Criteria: 1. ASA physical status classification I or II 2. Expected to be ventilated with a laryngeal mask airway (LMA) 3. Expected to have anesthesia titrated to insure continued spontaneous breathing Exclusion Criteria: 1. Patients whose surgery will last less than 70 minutes 2. Obese patients with BMI 30 kg/m2 or higher 3. Patients who will have thoracic or abdominal surgery 4. Patients with gastro-esophageal reflux disease 5. Patients who will needed muscle relaxants or are expected to require controlled ventilation during surgery 6. Patients with chronic obstructive pulmonary disease or asthma 7. Patients with neuromuscular disease or presenting with increased intracranial pressure 8. Patients with major cardiovascular disease, or cerebral vascular disease 9. Abnormal vital signs on the day of admission for surgery [heart rate (HR); >100 bpm or <40 bpm, Noninvasive blood pressure (NIBP); >180/100 mmHg or <90/60 mmHg or transcutaneous oxyhemoglobin saturation (SpO2); <94%] that are not correctable with his or her routine medication or commonly used pre-operative medication 10. Pregnant women and women less than one month post-partum. Pregnancy will be ruled out by careful history and physical examination. If history is equivocal, the subject will be excluded unless a negative pregnancy test is obtained 11. Emergent cases 12. Chronic opioid use |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Massachusetts General Hospital |
Pattinson KT. Opioids and the control of respiration. Br J Anaesth. 2008 Jun;100(6):747-58. doi: 10.1093/bja/aen094. Review. — View Citation
Yamanaka T, Sadikot RT. Opioid effect on lungs. Respirology. 2013 Feb;18(2):255-62. doi: 10.1111/j.1440-1843.2012.02307.x. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | End-tidal carbon dioxide measured by Capnograph monitor | end-tidal carbon dioxide (mmHg): this assessment relies on multiple measurements over time and the Time Frame includes multiple time points | 0, 5, 10, 15, 20, 25, 30 and 35 min after the initiation of PSV | |
Secondary | Respiratory rate measured by Respiratory monitor | respiratory rate (breath/min): this assessment relies on multiple measurements over time and the Time Frame includes multiple time points | 0, 5, 10, 15, 20, 25, 30 and 35 min after the initiation of PSV | |
Secondary | Expiratory tidal volume measured by Respiratory monitor | expiratory tidal volume (ml): this assessment relies on multiple measurements over time and the Time Frame includes multiple time points | 0, 5, 10, 15, 20, 25, 30 and 35 min after the initiation of PSV |
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