The Determination of the Effect of Volatile Anesthetics on Leukocyte Function ex Vivo

Anesthesia Clinical Trial

Official title:

The Determination of the Effect of Volatile Anesthetics on Leukocyte Function ex Vivo

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02207842
• Other study ID #: P00012751
• Status: Completed
• Phase: N/A
• First received: July 30, 2014
• Last updated: April 28, 2017
• Start date: November 2014
• Est. completion date: January 2017

Study information

• Verified date: April 2017
• Source: Boston Children’s Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

One of the most common side effects of a surgical procedure is infection. In order to lower the number of infections that occur after surgery, it is important for physicians to know how medications used during surgery affect the way the body fights infection. Often, when anesthesiologists are helping people go to sleep before surgery they give people medications known as "volatile anesthetics". Volatile anesthetics are medications that can change from a liquid or solid to a gas very easily. Some studies suggest that these types of medications may change the way white blood cells work in the body. Changing the way white blood cells work could possibly increase the person's risk of infection after their surgery or weaken their body's ability to fight infections. The goal of this research study is to learn about how volatile anesthesia medications change the way white blood cells work in people having anesthesia for cardiac procedures. To do this, investigators will examine the function of while blood cells in the laboratory based setting.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 41
• Est. completion date: January 2017
• Est. primary completion date: January 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 12 Months and older

Eligibility

Inclusion Criteria:

• Male and female patients

• greater than or equal to 12 months of age

• scheduled for a cardiac catheterization, cardiac surgery, or cardiac MRI

Exclusion Criteria:

• known underlying hematological disorder

• known oncological disorder

• patients who do not require preoperative laboratory testing

Related Conditions & MeSH terms

• Anesthesia
• Leukocyte Function

Locations

Country	Name	City	State
United States	Boston Children's Hospital	Boston	Massachusetts

Sponsors (1)

Lead Sponsor	Collaborator
Boston Children’s Hospital

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Leukocyte function under anesthesia	The study will evaluate ex vivo leukocyte function by testing leukocyte activation, TNF-a production, and phagocytic function in the laboratory.	up to 12 months