Application of Combined Lumbar Plexus and Sciatic Nerve Block

Anesthesia Clinical Trial

Official title:

Application of Combined Lumbar Plexus and Sciatic Nerve Block in Unilateral Knee Replacement

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02084368
• Other study ID #: Nerve Block
• Status: Completed
• Phase: Phase 4
• First received: March 6, 2014
• Last updated: September 10, 2014
• Start date: January 2014
• Est. completion date: February 2014

Study information

• Verified date: September 2014
• Source: Guangzhou General Hospital of Guangzhou Military Command
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The research is to study the effectiveness and safety of combined lumbar plexus and sciatic nerve block by the guide of peripheral nerve stimulator (PNS) in unilateral knee replacement.There have be some papers which supported that combined lumbar plexus and sciatic nerve block may be more suitable for the old men.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 34
• Est. completion date: February 2014
• Est. primary completion date: February 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 85 Years

Eligibility

Inclusion Criteria:

1. Patients of American Association of anesthetists(ASA)Grade 1?2 or 3

2. Aged between 18 and 85 years

3. Undergoing elective total knee replacement.

Exclusion Criteria:

1. Mental illness can not match

2. Nerve block, epidural anesthesia contraindicated

3. People who have Slow-type arrhythmias

4. History of chronic headaches and long-term use of analgesic drugs

5. People who were postoperative consciousness, language or hearing impaired

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Anesthesia

Intervention

Procedure:
• Nerve block
Patients in this group were assigned to receive lumbar plexus block and sciatic nerve block both using 0.33% ropivacaine 30ml guided by PNS
• Combined spinal and epidural anesthesia
Combined spinal and epidural anesthesia were performed in patients of this group with 0.5% hyperbaric bupivacaine 8~10mg at L2-3 or L3-4.

Drug:
• Ropivacaine
Patients will be assigned to receive lumbar plexus block and sciatic nerve block both using 0.33% ropivacain 30ml guided by PNS.
• Bupivacaine
Combined spinal and epidural anesthesia will be performed in patients with 0.5% hyperbaric bupivacaine 8~10mg.

Locations

Country	Name	City	State
China	Guangzhou Military Region General Hospital, Department of Anesthesiology	Guangzhou	Guangdong

Sponsors (1)

Lead Sponsor	Collaborator
Guangzhou General Hospital of Guangzhou Military Command

Country where clinical trial is conducted

China, 

References & Publications (2)

de Leeuw MA, Slagt C, Hoeksema M, Zuurmond WW, Perez RS. Hemodynamic changes during a combined psoas compartment-sciatic nerve block for elective orthopedic surgery. Anesth Analg. 2011 Mar;112(3):719-24. doi: 10.1213/ANE.0b013e318206bc30. Epub 2010 Dec 14 — View Citation

Farny J, Girard M, Drolet P. Posterior approach to the lumbar plexus combined with a sciatic nerve block using lidocaine. Can J Anaesth. 1994 Jun;41(6):486-91. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Maintenance time of sensory and motor nerve block	from the end of injection of local anesthetic drug up to 24h after operation	up to 24h after operation	Yes
Secondary	The change of hemodynamics	the changes of SBP and DBP at 0, 5, 10, 20, 30, 60 min after injection	0, 5, 10, 20, 30, 60 min after injection	Yes