Anesthesia Clinical Trial
Official title:
Anesthetic Advantages of Dexmedetomidine Compared With Nitroglycerin for Hypotensive Anesthesia in Orthognathic Surgery. A Randomized Clinical Trial.
The aim of this study was to evaluate the positive anesthetic properties such as reduce intraoperative analgesic requirement, time to extubation and recovery, and early postoperative pain of dexmedetomidine used as a hypotensive agent compared with nitroglycerin.
The subject included the healthy patients who underwent orthognathic surgery and gave
written the informed consent. The sample size was calculate from the amount of fentanyl use
in orthognathic surgical case and difference more 30% was significant. Randomization was
done by random number table to 2 groups. Both groups received standardized controlled
hypotensive anesthesia and surgery. D group used dexmedetomidine as the hypotensive drug and
N group use nitroglycerin. The main outcome were the amount of fentanyl use, time to eye
opening, follow simple command, extubation, early postoperative pain, and early
postoperative amount of pain killer. All recorded by anesthesiologist on data sheet.
compare statistical analysis used compare mean by unpaired student t test.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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