1-1-12 Wash-in for Desflurane Low Flow Anesthesia

Anesthesia Clinical Trial

Official title:

1-1-12 Wash-in for Desflurane Low Flow Anesthesia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02013882
• Other study ID #: HE561247
• Status: Completed
• Phase: N/A
• First received: December 5, 2013
• Last updated: February 8, 2014
• Start date: January 2014
• Est. completion date: January 2014

Study information

• Verified date: February 2014
• Source: Khon Kaen University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Thailand: Khon Kaen University Ethics Committee for Human Research
• Study type: Observational

Clinical Trial Summary

We propose a new wash-in technique for desflurane low flow anesthesia with fresh gas flow of O2:N2O 1:1 L/min with desfluraene 12%.

The objective of this study is to identify time to achieve alveolar concentration of desflurane at1, 2, 3, 4, 5 and 6%.

Description:

The benefits of low flow anesthesia are economic, less pollution, more heat and humidity preservation but it requires appropriate wash-in phase. The current wash-in protocols are complicated and time consuming. We propose a new 1-1-12 desflurane wash-in protocol which is more simple and predictable.

The objective of this study is to identify time to achieve alveolar concentration of desflurane at 1, 2, 3, 4, 5 and 6% with 1-1-12 wash-in protocol.

All patients will receive iv propofol 2 mg/kg as induction agent and succinyl choline 1.5 mg/kg for intubation. Then the ventilation will be controlled to achieve end-tidal CO2 30-35 mmHg with O2:N2O 1:1 L/min with desflurane 12%. Time to achieve alveolar concentration of desflurane at 1, 2, 3, 4, 5 and 6% will be recorded and analyzed. After that, the concentration of desflurane and anesthetic technique will be adjusted to requirement of anesthesiologist.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 106
• Est. completion date: January 2014
• Est. primary completion date: January 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 64 Years

Eligibility

Inclusion Criteria:

• ASA classification I-II

• age 18-64 years

Exclusion Criteria:

• BMI > 35

• contraindicated for N2O

• with pulmonary or cardiac disease

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Anesthesia

Intervention

Procedure:
• 1-1-12 wash-in
wash-in phase during start of low flow anesthesia

Locations

Country	Name	City	State
Thailand	Srinagarind Hospital	Khon Kaen

Sponsors (1)

Lead Sponsor	Collaborator
Khon Kaen University

Country where clinical trial is conducted

Thailand, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Time (in second) to achieve alveolar concentration of desflurane 1, 2, 3, 4, 5 and 6%		participants will be followed until alveolar concentration of desflurane reaches 6%, as expected of 15 minutes	No
Secondary	Heart rate		participants will be followed until alveolar concentration of desflurane reaches 6%, as expected of 15 minutes	No