Anesthesia Clinical Trial
Official title:
Repeatability and Reproducibility of the Measurement of Young's Modulus Using Shear Wave Elastography in Volunteers
The aim of the study is to assess the accuracy of shear wave elastography in volunteers. Shear wave elastography is a non-invasive, non-painful measure of tissue stiffness obtained using an ultrasound machine. It may be easier to think of shear wave elastography as a special type of ultrasound imaging which gives doctors a colour picture of body structures based on their stiffness.
Shear wave elastography is a quantitative ultrasound modality increasingly used to
differentiate between "hard" breast cancer masses and "soft" normal tissue. Unlike strain
elastography, shear wave elastography applies a non-compressive longitudinal acoustic
radiation force to underlying tissues, inducing transverse shear waves. Studies in Thiel
embalmed human cadavers have shown significant differences in Young's modulus between
intraneural and extraneural tissue, and ready colour differentiation between tissues.
Therefore, before clinical application, we wish to measure the repeatability and
reproducibility of Young's modulus of intraneural and extraneural tissue in volunteers. For
measurement, a region of interest (ROI) will be selected over the appropriate nerve and
adjacent tissue. The ROI results will be regarded as paired data. Paired data will be
measured over and adjacent to the interscalene C5 nerve root, infraclavicular lateral cord,
musculocutaneous, median, femoral, saphenous and sciatic nerves.
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