Anesthesia and Lymphocytes Apoptosis

Anesthesia Clinical Trial

— OPCAB  

Official title:

Different Effects of Sevoflurane, Propofol and Combine of Sevoflurane and Propofol Maintained Anesthesia on Peripheral Blood Lymphocytes During Off-pump Coronary Artery Bypass Graft Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01461551
• Other study ID #: OPCAB
• Status: Completed
• Phase: N/A
• First received: October 19, 2011
• Last updated: May 6, 2015
• Start date: October 2011
• Est. completion date: October 2014

Study information

• Verified date: May 2015
• Source: Ruijin Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

Most researches revealed that volatile anesthetic sevoflurane has a more marked cardioprotective effect against ischemia compared with intravenous agent propofol.However, propofol has been suggested to be more benefit for attenuation of surgery-induced immunosuppression.Thus, the aim of this study was to investigate under the specific OPCAB surgical stress, the influence of 3 established anesthetic techniques: sevoflurane, propofol and combine of sevoflurane and propofol maintained anesthesia on the apoptosis of circulating lymphocytes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 105
• Est. completion date: October 2014
• Est. primary completion date: February 2012
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• male adults

• aged 18-80 yr

• undergoing elective OPCAB surgery containing left anterior descending artery bypass

Exclusion Criteria:

• a previous unusual response to any of the experimental anesthetics

• severe cardiac dysrhythmias or ejection fraction below 30%

• hemodynamic instability

• previous surgical coronary artery repair

• anemia, abnormal leukocytes or coagulopathy

• severe hypertension

• severe hepatic (albumin<30g,ascites), renal (serum creatinine greater than 2.0 mg/dl) or pulmonary (preoperative pulmonary function tests moderate-severe) dysfunctions

• concomitant surgical procedures and psychiatric disorders

• Insulin-dependent diabetics

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Anesthesia

Intervention

Drug:
• Sevoflurane
anesthesia was maintained with sevoflurane (end-tidal concentration 1.0-1.5 minimum alveolar concentration)
• Propofol
anesthesia was maintained with propofol (2-4 µg/ml via target-controlled infusion)
• combine of sevoflurane and propofol
anesthesia was maintained with a combine of propofol (1 µg/ml via target-controlled infusion) and sevoflurane (end-tidal concentration 0.7-1.0 minimum alveolar concentration)

Locations

Country	Name	City	State
China	Ruijin Hospital	Shanghai	Shanghai

Sponsors (1)

Lead Sponsor	Collaborator
Ruijin Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Lymphocyte Count	Blood samples were obtained 24 h after the surgery for routine blood examination. This analysis was performed in the hospital laboratory using routine laboratory procedures.	1 day after surgery	Yes
Secondary	Intensive Care Unit Staying Days		participants will stay in intensive care unit after surgery, an expected average of 2 days	Yes

External Links

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