Dexamethasone and Analgesic Duration After Supraclavicular Brachial Plexus Blockade

Anesthesia Clinical Trial

Official title:

Dexamethasone and Analgesic Duration After Supraclavicular Brachial Plexus Blockade

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00802009
• Other study ID #: 08-0896-B
• Status: Completed
• Phase: N/A
• First received: December 2, 2008
• Last updated: January 22, 2010
• Start date: May 2009
• Est. completion date: November 2009

Study information

• Verified date: January 2010
• Source: University Health Network, Toronto
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: Canadian REB
• Study type: Interventional

Clinical Trial Summary

Patients undergoing surgery of the hand often are treated with a nerve block in the shoulder/neck area that provides anesthesia/numbing during surgery. Nerve blocks usually last for a few hours after surgery and provide pain relief for this period. It may be possible to extend the duration of anesthesia by using a steroid, which has anti-inflammtory properties. This study will compare the duration of the nerve block when dexamethasone (steroid) is added to the anesthetic injected around the nerve.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 44
• Est. completion date: November 2009
• Est. primary completion date: October 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

1. Patients having unilateral hand or forearm surgery under Supraclavicular brachial plexus blockade.

2. ASA I-III

3. Age 18-60

4. BMI < 35

Exclusion Criteria:

1. Patients with a known history of hypersensitivity to local anesthetics and dexamethasone.

2. Contra-indication to regional anesthesia/ supraclavicular brachial plexus blockade e.g. bleeding diathesis, coagulopathy.

3. Peripheral neuropathy.

4. Peptic ulcer disease.

5. Diabetes Mellitus.

6. Inability to give informed consent.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Anesthesia

Intervention

Drug:
• Dexamethasone
Dexamethasone 8 milligrams (liquid) will be added to standard anesthetic solution administered during routine brachial plexus nerve blockade.
• Mepivicaine
Standard anesthetic solution administered during routine brachial plexus nerve blockade.

Locations

Country	Name	City	State
Canada	Toronto Western Hospital, University Health Network	Toronto	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
University Health Network, Toronto

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Duration of anesthesia		hourly for first 24 hours; daily until discharge	No
Secondary	Requirements for pain medications; complications		up to 3 months	No