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Anesthesia clinical trials

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NCT ID: NCT02846129 Completed - Anesthesia Clinical Trials

Incidence of Complications Associated With Anesthesia in Multiple Gestation Undergoing Cesarean Delivery

Start date: October 2016
Phase: N/A
Study type: Observational

Incidence of anesthesia related complications in multiple gestation patients undergoing cesarean delivery has not been reported in Thailand. The aim of this study is to identify complications that occur which may derived from different anesthetic techniques used, such as hypotension, uterine atony, postpartum hemorrhage, rate of hysterectomy, blood transfusion and fetal outcome.

NCT ID: NCT02832596 Completed - Anesthesia Clinical Trials

Changes in Measured Plasma Volume, Glycocalyx and Atrial Natriuretic Peptide During Anaesthesia

Start date: October 2016
Phase: N/A
Study type: Interventional

The arterial blood pressure is thought to affect the ratio between filtration and reabsorption of fluids in the circulating blood volume and thereby the plasma volume. During induction of anesthesia blood pressure, hemoglobin level and hematocrits decreases and the plasma volume increases. The aim of the study is to evaluate weather a maintained blood pressure with norepinephrine during anesthesia induction reduces the increase in 125 iodine-labeled human serum albumine (125I-HSA) measured plasma volume.

NCT ID: NCT02830516 Completed - Anesthesia Clinical Trials

Intraoperative Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods.

Lungbaro
Start date: June 2016
Phase: N/A
Study type: Observational

Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations i esophagus pressure divided by the tidal volume. This requires the presence of a esophageal balloon catheter which is cumbersome and costly. In this study values obtained as described above are compared to values obtained with a new method in which a stepwise increase in positive endexpiratory pressure (PEEP) is performed with a size which corresponds to the tidal volume which the patient is ventilated with. These measurements are performed in anesthetized patients prior to major surgery.

NCT ID: NCT02830243 Completed - Anesthesia Clinical Trials

Comparison of Analgesic Effect of Volatile Anesthetics

Start date: July 12, 2016
Phase: Phase 3
Study type: Interventional

The purpose of this clinical trial is to compare analgesic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using surgical pleth index.

NCT ID: NCT02819375 Completed - Anesthesia Clinical Trials

Comparison of Propofol, Propofol-remifentanil and Propofol-ketamine Anesthesia During Electroconvulsive Therapy

Start date: January 2017
Phase: Phase 4
Study type: Interventional

Electroconvulsive therapy (ECT) is a common treatment method used in severe depression and other psychiatric diseases. Currently, most ECT procedures are carried out with muscle paralysis under general anaesthesia. The anticonvulsant properties of sedative and hypnotic drugs used during general anaesthesia may reduce the efficacy of ECT. It is important to establish an accurate balance between adequate anaesthesia depth and optimal seizure duration. We aimed to compare the effectiveness of three anaesthetic regimens (propofol alone, propofol with remifentanil and propofol with ketamine), with respect to seizure duration and seizure quality in patients undergoing electroconvulsive therapy.

NCT ID: NCT02812927 Completed - Anesthesia Clinical Trials

Evaluation of Glycemic Variability (GLAIVE)

GLAIVE
Start date: September 2012
Phase: N/A
Study type: Interventional

This study compared two methods of insulin infusion by syringe pumps to assess the impact of medical devices on the glycaemic variability in patients under IIT in ICU. The main objective of the study was to show the superiority of the infusion system which permitted to dedicate a line for the insulin administration on the "standard" installation in terms of control of glycaemic variability.

NCT ID: NCT02809378 Completed - Anesthesia Clinical Trials

The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONV

Start date: June 2016
Phase: Phase 4
Study type: Interventional

The incidence of postoperative nausea and vomiting (PONV) after thyroidectomy have been shown to be relatively high compared other surgeries, with a reported incidence 65-75 %. PONV may increase patient discomfort, delay patient discharge, and increase the cost of patient care, the risk of postoperative bleeding which may potentially cause airway obstruction. It is reported that the maintenance of anesthesia with propofol-remifentanil or sevoflurane-propofol-remifentanil decreased the incidence of PONV compared sevoflurane alone, but failed to demonstrate the decreased incidence of PONV in 6-24 hr postoperative period in patients undergoing thyroidectomy. Administration of Palonosetron, newly developed 5-HT3 antagonists with long half life (48 hrs) may decrease the incidence of PONV particularly during this period. The purpose of this study was to evaluate and compare the incidence of PONV after thyroidectomy with three different anesthetic methods, sevoflurane or sevoflurane-propofol-remifentanil or sevoflurane-propofol-remifentanil-palonosetron in woman patients.

NCT ID: NCT02806596 Completed - Anesthesia Clinical Trials

Bispectral Index to Guide Intubation in Pediatric Anesthesia

Start date: January 2010
Phase: N/A
Study type: Interventional

This prospective study aimed to determine the minimal level of Bispectral index needed for quality laryngoscopy before ear, nose and throat surgery in children.

NCT ID: NCT02794896 Completed - Anesthesia Clinical Trials

Anesthetic Depth Effects Upon Immune Competent Cells

BIS-MA
Start date: March 2009
Phase: N/A
Study type: Interventional

Anesthesia depth affects the proliferation of lymphocytes to NK-cells and memory T-cells effect and the phagocytosis activity of macrophages in healthy patients. ASA 1-3 subjects undergoing extended shoulder surgery under continuous regional anesthesia randomly were assigned to a deep or a shallow anesthesia level (BIS <35 or >55) for more than an hour. Immune response is measured by lymphocyte proliferation as well as neutrophil and monocyte phagocytosis activity.

NCT ID: NCT02794532 Completed - Anesthesia Clinical Trials

PreOxygenation In RSI Anesthesia

PRIOR
Start date: June 1, 2016
Phase: N/A
Study type: Interventional

Pre-oxygenation with high-flow nasal cannula oxygen has been evaluated in a limited number of studies and seems to be better than traditional preoxygenation with a tight fitting mask. Oxygenation with high-flow nasal cannula in apnea demonstrates that this could be done safely for up to 25 mins with preserved saturation. Based on this, the investigators want to evaluate whether this novel concept of preoxygenation can prolong the time to desaturation in emergency anesthesia while securing a possibly difficult airway. This may reduce the number of hypoxic events during intubation. This novel concept has already been tested in clinical practice in certain cases but not during rapid sequence induction for acute surgery. Objectives and Purpose The general purpose of this project is to compare a new preoxygenation technique based on humidified oxygen in a high-flow nasal cannula with traditional preoxygenation with a tight fitting mask during rapid sequence induction intubation with focus on gas exchange.