Anesthesia Recovery Period Clinical Trial
Official title:
Effects of Hypercapnia on Emergence From General Anesthesia Under Propofol: a Pilot Study
Hypercapnia derives increase of cerebral blood flow and cardiac output. It means that the rate of propofol elimination from the brain and the blood will be increased and the patient will awake more quickly. There has been no study about the effects of hypercapnia. The investigators will evaluate hypercapnia's effects on the recovery time from propofol anesthesia.
Status | Completed |
Enrollment | 30 |
Est. completion date | June 2013 |
Est. primary completion date | June 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 20 Years to 60 Years |
Eligibility |
Inclusion Criteria: - American Society of Anesthesiologists physical status (ASA PS) I-II - Age 20 - 60 years male and female - Elective schedule with minor surgery under general anesthesia Exclusion Criteria: - Body mass index (BMI) >= 30 (kg/m2) - Patient with pulmonary, cardiac, endocrinal, neuromuscular and neurological diseases or past history - Patient with medication affecting on this study - Patient with general anesthesia history within one month |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor)
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Dept. of anesthesiology and pain medicine, Dongguk University Ilsan Hospital | Goyang | Kyunggido |
Lead Sponsor | Collaborator |
---|---|
DongGuk University |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Time to open eyes under investigator's command | After stopping propofol infusion, every 30 seconds, the investigator (caregiver) will command the patient, "Open your eyes". When the patient opens eyes, the time will be recorded. The patients will be followed for an expected average of 10 minutes. | From cessation of propofol infusion to patient's eye opening (seconds) | No |
Secondary | Time to breath spontaneously | The time from cessation of propofol infusion to patient's spontaneous breaths will be recorded. The patients will be followed for an expected average of 10 minutes. | From cessation of propofol infusion to patient's spontaneous breathing (sec) | No |
Secondary | Change of bispectral index (BIS) | After stopping propofol infusion, the BIS and time (seconds) will be recorded and reviewed. These will be recorded for an expected average of 15 minutes. | From the cessation of propofol infusion to extubation, BIS and time (seconds) will be recorded. | No |
Secondary | Time to open mouth under investigator's command | After the patient opens the eyes, every 10 seconds, the investigator command the patient, "Open your mouth.". When the patient opens mouth, the time will be recorded. The patients will be followed for an expected average of 12 minutes. | From cessation of propofol infusion to patient's mouth opening (seconds) | No |
Secondary | Time to extubation | After stopping propofol infusion, When the patient breaths spontaneously with adequate tidal volume and respiratory rates, the trachea will be extubated and the time will be recorded. The patients will be followed for an expected average of 15 minutes. | From cessation of propofol infusion to extubation (sec) | No |
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