Clinical Trials Logo
  1. Home
  2. Anesthesia, Intravenous
  3. NCT03661489

Efficacy and Safety of Remimazolam (CNS7056) Compared to Propofol for Intravenous Anesthesia During Elective Surgery

Anesthesia, Intravenous Clinical Trial

Official title:
Phase III Confirmatory Efficacy and Safety Trial of Remimazolam (CNS7056) Compared With Propofol for Intravenous Anesthesia During Elective Surgery in ASA Class III/IV Patients

Clinical Trial Summary

A phase III confirmatory trial evaluating the efficacy and safety of remimazolam (CNS7056) compared to propofol for intravenous anesthesia during elective surgery in ASA Class III/IV patients.

Clinical Trial Description

This is a Phase III single-blind, randomized, controlled, non-inferiority multi-center trial in American Society of Anesthesiologists (ASA) Class III/IV patients undergoing elective surgery, comparing remimazolam to propofol for induction and maintenance of intravenous anesthesia. In accordance with general anesthetic standard regimen, remimazolam or propofol, will be administered together with remifentanil as analgesic agent, and with a neuromuscular blocker to facilitate intubation and achieve muscle relaxation ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03661489
Study type Interventional
Source Paion UK Ltd.
Contact
Status Completed
Phase Phase 3
Start date July 24, 2018
Completion date April 2, 2020
View Details
See also
  Status Clinical Trial Phase
Completed NCT03861364 - Hemodynamics During Induction of General Anesthesia With High and Low Propofol Dose. Phase 4
Not yet recruiting NCT06092684 - The Efficacy and Safety of Esketamine in Elective Laparoscopic Surgery Phase 3
Not yet recruiting NCT04266535 - TCI vs Manually Controlled Infusion of Propofol
Recruiting NCT03864094 - Hemodynamics During Induction of General Anesthesia After Prophylactic Ephedrine, Phenylephrine or Norepinephrine. Phase 4
Not yet recruiting NCT06237101 - Remifentanil Effect on Burst Suppression Ratio N/A
Completed NCT03861377 - Hemodynamics During Induction of General Anesthesia With Medium or Low Remifentanil Doses. Phase 4
Completed NCT02492282 - Evaluation of a Novel Closed-loop Propofol and Remifentanil System Guided by Bispectral Index Compared to a TCI Open-loop System Phase 3
Completed NCT02197858 - Comparability of Invasive and Non-invasive Haemodynamic Monitoring N/A
Recruiting NCT03428191 - Target Effect-site Concentration of Remifentanil in Transperineal Prostate Puncture N/A
Completed NCT02527083 - Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain Phase 4
Completed NCT01531491 - Effects of Hypercapnia on Emergence From General Anesthesia Under Propofol N/A
Recruiting NCT00378170 - Laryngoscope Prototype Tested Against the Traditional Macintosh Blade N/A
Completed NCT03614325 - Virtual Reality in the Operating Room N/A
Completed NCT05047939 - Comparison of Recovery Profile After TIVA Between Remimazolam With Flumazenil and Propofol N/A
Completed NCT02706431 - Oxygenation by 100% Oxygen Via High Flow Nasal Cannula in Surgical Patients N/A
Withdrawn NCT04586998 - Comparison Between Propofol Concentration in Exhaled Breath and Blood Plasma Using the Exhaled Drug Monitor "Edmon" N/A
Active, not recruiting NCT05343260 - Impact of Anesthesia Maintenance Methods on 5-year Survival After Surgery N/A
Completed NCT02660411 - Impact of Anesthesia Maintenance Methods on Long-term Survival N/A