Clinical Trials Logo

Clinical Trial Summary

Objective: The present study was to evaluate the effects of dexmedetomidine alone, lidocaine alone and their combined infusion on postoperative inflammation cytokines after Laparoscopic hysterectomy. Methods: Investigators enrolled 160 women with American Society of Anesthesiologists (ASA) physical status I and II, aged 40-65 years, and scheduled for elective laparoscopic hysterectomy with general anesthesia from October 2017 to August 2018. The participants were randomly assigned into four groups(n=40 each group): group CON received normal saline infusion, group LIDO received lidocaine infusion (1.5 mg/kg loading, 1.5 mg/kg/h infusion), group DEX received dexmedetomidine infusion (0.5 µg/kg loading, 0.4 µg/kg/h infusion) and group LIDO+DEX received lidocaine (1.5 mg/kg loading, 1.5 mg/kg/h infusion) and dexmedetomidine infusions (0.5 µg/kg loading, 0.4 µg/kg/h infusion). The four groups received an IV bolus infusion of normal saline, lidocaine, dexmedetomidine and lidocaine combined with dexmedetomidine respectively, over 10 minutes before induction of anesthesia, followed by a continuous IV infusion of normal saline, lidocaine, dexmedetomidine and lidocaine combined with dexmedetomidine until abdominal wound closure, respectively. Interleukin-6 and tumor necrosis factor-α levels in serum were measured at different time points: before administration of drugs (T1), the end of surgery (T2), postoperative 2 hour (T3) and postoperative 24 hour (T4).


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03276533
Study type Interventional
Source Anqing Municipal Hospital
Contact
Status Completed
Phase N/A
Start date November 1, 2017
Completion date August 10, 2020

See also
  Status Clinical Trial Phase
Recruiting NCT05358535 - Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial) Phase 3
Recruiting NCT03839784 - Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
Completed NCT04399226 - Dexmedetomidine-Propofol and Ketamine-Propofol During Upper Gastrointestinal System Sedation
Recruiting NCT05024838 - Prediction of Block Height of Spinal Anesthesia
Completed NCT05383417 - No Post Intubation Laryngeal Symptoms N/A
Enrolling by invitation NCT02104908 - Study of Nerve Block Anesthesia for Surgery of Hip Fracture in the Elderly Phase 4
Recruiting NCT01329874 - Anesthetic Efficacy of Gow-Gates Versus Conventional Inferior Alveolar Nerve Block Techniques N/A
Completed NCT01651988 - Efficacy of Ketamine-Propofol for Short Surgical Procedures Phase 4
Recruiting NCT01898897 - Influence of Anesthesia Technique on Postoperative Evolution After Urogenital Surgical Interventions N/A
Recruiting NCT04435834 - Individual Cerebral Hemodynamic Oxygenation Relationships Phase 4
Not yet recruiting NCT02143362 - Dexmedetomidine Combined With the Closed Loop of Target Controlled Infusion of Propofol for Anesthesia With Intraoperative Wake up Phase 4
Completed NCT02136641 - Study of Comparison of the Effectiveness of Three Diagrams for Sedation in Spinal Anesthesia Phase 4
Completed NCT02429323 - Endotracheal Intubation With Sevoflurane in Surgical Pediatric Patients N/A
Not yet recruiting NCT05869578 - Registry of Anesthesia and Perioperative Medicine
Completed NCT03134677 - The Effects of Different Anesthetic Techniques on QT, Corrected QT (QTc), and P Wave Dispersions in Cesarean Section Phase 4
Enrolling by invitation NCT02355093 - Adductor Canal Block Versus Femoral Nerve Block for Analgesia After Anterior Cruciate Ligament Reconstruction Arthroscopically Phase 4
Completed NCT03161275 - Measurement of the Cerebral Saturation for Assessment of Safety of Epidural Anaesthesia During Abdominal Surgery N/A
Recruiting NCT03237429 - The Relationship Between BCM, Arterial Stiffness and Hemodynamic Instability During Induction of General Anesthesia
Active, not recruiting NCT05610007 - Comparison of Hyperbaric Prilocaine 2% 50 Mg and Hyperbaric Bupivacaine 0.5% 12.5 Mg Against Spinal Anesthesia Recovery Time in Cystoscopy Procedure Phase 4
Completed NCT04906772 - Dexmedetomidine-ketamine Versus Propofol-ketamine for Sedation During Endoscopy in Hepatic Patients Phase 4