The Effect of General and Spinal Anesthesia on Neutrophil-to-lymphocyte Ratio

Anesthesia, General Clinical Trial

Official title:

Comparison of the Effect of General and Spinal Anesthesia on Umbilical Neutrophil-to-lymphocyte Ratio, Platelet-to-lymphocyte Ratio and Mean Platelet Volume in Patients Undergoing Cesarean Section

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05409885
• Other study ID #: 5/4
• Status: Completed
• Start date: March 20, 2022
• Est. completion date: July 7, 2022

Study information

• Verified date: April 2022
• Source: Antalya Training and Research Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of the study was to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients undergoing cesarean section.

Description:

This study was designed to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord NLR, PLR and MPV in patients undergoing cesarean section. The primary endpoint was to compare the effects of general and spinal anesthesia on umbilical cord NLR. Secondary endpoints were determined the general and spinal anesthesia on routine umbilical cord PLR, MPV and newborn Apgar scores at 1st and 5th min.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: July 7, 2022
• Est. primary completion date: July 1, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• 18 - 45 years
• American Society of Anesthesiology (ASA) II-III
• elective ceserean surgery

Exclusion Criteria:

• declining to give written informed consent
• under 18 years of age or over 45 years of age
• factors affecting NLR, PLR and MPV such as preeclampsia, HELLP syndrome or premature rupture of membranes
• history of neurological and/or neuromucular disease
• cooperation cannot be established
• emergency surgery

Related Conditions & MeSH terms

• Anesthesia, General
• Anesthesia, Spinal
• Umbilical Cord

Intervention

Other:
• General anesthesia
Evaluate the effects of general anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.
• Spinal anesthesia
Evaluate the effects of spinal anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Locations

Country	Name	City	State
Turkey	Antalya Training and Research Hospital, Department of Anesthesiology and Reanimation	Antalya

Sponsors (1)

Lead Sponsor	Collaborator
Antalya Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	neutrophil-to-lymphocyte ratio	Evaluate the effects of NLR in patients undergoing cesarean section	within 5 minute, following delivery
Secondary	platelet-to-lymphocyte ratio	Evaluate the effects of PLR in patients undergoing cesarean section	within 5 minute, following delivery
Secondary	mean platelet volume	Evaluate the effects of MPV in patients undergoing cesarean section	within 5 minute, following delivery
Secondary	Newborn Apgar score 1st minute	Appearance (skin color), Pulse (heart rate), Grimace (reflex irritability), Activity (tone), Respiration. Apgar score at 1st min (0-3: severely depressed, 4-6: moderately depressed, 7-10: excellent condition)	1st minute after birth
Secondary	Newborn Apgar score 5th minute	Appearance (skin color), Pulse (heart rate), Grimace (reflex irritability), Activity (tone), Respiration. Apgar score at 1st min (0-3: severely depressed, 4-6: moderately depressed, 7-10: excellent condition)	5th minute after birth