Anemia Clinical Trial
Anaemia is the most worldwide health problem affecting pregnant women in both developed and
developing countries. During pregnancy there is an inconsistent increase in plasma volume
and haemoglobin mass.
Iron deficiency anemia is the commonest type of anemia during pregnancy. The pregnant woman
needs about 1000 mg of iron during pregnancy.
Diet alone cannot give pregnant woman the daily required amount of the iron (about 27
mg/day) so the Centers for Disease Control and Prevention recommend that pregnant women take
a daily supplement of 30 mg of elemental iron as a preventive dose. As most women begin
their pregnancy with low iron stores, particularly in the second and third trimesters, so
prevention should start as soon as possible even before pregnancy to prevent depletion of
iron store and further Iron deficiency anemia.
Oral iron is a cheap, effective and relatively safe line to prevent Iron deficiency anemia
during pregnancy. The common available ferrous salts include ferrous fumarate, ferrous
sulphate and ferrous gluconate. Unfortunately; these iron forms are associated usually with
constipation, darkened stools, diarrhea, loss of appetite, nausea, stomach cramps, and
vomiting.
Iron amino acid chelates have been emerged to be used as agents for prevention and treatment
of Iron deficiency anemia. These agents provide maximum bioavailability and maximum efficacy
with minimal unpleasant side effects.
Twin pregnancies have a significant role in perinatal morbidity due to increased risks of
low birth weight and preterm birth. The iron requirement for twin pregnancy is probable
double fold that of a singleton pregnancy and maternal hemoglobin in twin gestations is
usually lower than in singleton pregnancy resulting in higher rate of Iron deficiency
anemia.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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