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NCT05330754 Clinical Trial

Caffeine Intake Inrelation to Perioperative Analgesic Consumption

Analgesia Clinical Trial

Official title:
Effect Of Daily Caffeine Intake On Perioperative Analgesic Consumption And Recovery Time In Patients Undergoing Laparoscopic Surgeries.

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05330754
Other study ID # R 67/ 2022
Secondary ID
Status Completed
Phase
First received
Last updated
Start date April 20, 2022
Est. completion date September 10, 2022

Study information
Verified date November 2022
Source Ain Shams University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Caffeine is the most widely consumed psychoactive drug in the world. Natural sources of caffeine include coffee, tea, and chocolate. Synthetic caffeine is also added to products to promote arousal, alertness, energy, and elevated mood. We designed this prospective observational study to determine if caffeine consumption would influence intraoperative analgesic consumption

Description:

Caffeine is a well-known natural compound present in various plant products. Caffeine is an integral component of several daily drinks, including tea, coffee, soft drinks, and energy drinks [1]. (e consumption habits of these caffeinated drinks have facilitated the wide distribution of and dependence on caffeine. For instance, 89% of the US adult population has an average caffeine intake of 200 mg/day [2]. Among the multiple effects and side effects, caffeine also has an analgesic action and is used to reduce pain in several pharmaceutical forms as an adjuvant [1]. Several studies have reported a role for caffeine in controlling pain and suggested that caffeine may block the central processing of pain signals in the brain and enhance the body's natural pain resistance pathways [3]. In addition, Overstreet et al. found that habitual caffeine consumption diminishes pain sensitivity in a laboratory setting [4]

Recruitment information / eligibility
Status Completed
Enrollment 90
Est. completion date September 10, 2022
Est. primary completion date August 30, 2022
Accepts healthy volunteers No
Gender All
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria: - Patients scheduled to undergo elective laparoscopic surgery Exclusion Criteria: - Patients converted to an open surgery, postoperative complications that increased postoperative pain, and those with psychological or nervous system diseases were also excluded. Liver disease

Study Design

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• Caffeine intake in mg
Preanesthetic check-up was done. Average daily caffeine consumption in mg was calculated according to "caffeine content in consumed drinks" as estimated by "Food Data Central".

Locations
Country Name City State
Egypt Ain Shams University Hospitals Cairo

Sponsors (1)
Lead Sponsor Collaborator
Ain Shams University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary total intraoperative fentanyl consumption in microgram Amount of total intraoperative fentanyl consumption in microgram 2 hours
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