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Chemoradiotherapy Combined With or Without PD-1 Blockade in Anal Canal Squamous Carcinoma Patients

Anal Cancer Clinical Trial

Official title:
A Phase 3, Multicenter, Double-Blind Randomized Study of Mitomycin, 5-Fluorouracil and IMRT Combined With or Without Anti-PD-1 in Patients With Locally Advanced Anal Canal Squamous Carcinoma

Clinical Trial Summary

This is a phase III, multi-center, double-blind randomized controlled trial assessing the efficacy and safety of concurrent mitomycin C/5-Fu chemotherapy and long-course IMRT combined with PD-1 antibody Sintilimab for locally advanced anal canal squamous carcinoma patients, by comparing an experiment group (traditional chemoradiotherapy with PD-1 antibody Sintilimab) with a control group (traditional treatment without Sintilimab).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05374252
Study type Interventional
Source Sixth Affiliated Hospital, Sun Yat-sen University
Contact Xiang-bo Wan, PhD
Phone +86-13826017157
Email wanxbo@mail.sysu.edu.cn
Status Recruiting
Phase Phase 3
Start date May 7, 2022
Completion date December 31, 2025
View Details
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