Clinical Trials Logo
  1. Home
  2. Anal Fissure Chronic
  3. NCT05616455

Efficacy and Safety of Propionibacterium Extract Gel Versus 0.4% Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: a Randomised Controlled Trial

Anal Fissure Clinical Trial

Official title:
Efficacy and Safety of Propionibacterium Extract Gel Versus 0.4% Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: a Randomised Controlled Trial

Clinical Trial Summary

The study compares the efficacy and safety of a Propionibacterium extract gel with 0.4% glyceryl trinitrate ointment in the treatment of chronic anal fissure.

Clinical Trial Description

Patients were randomly allocated to a PeG or GTN group and medication was taken every 12 hours for 40 days. Primary outcome was the success rate as measured by a decrease in the REALISE score at 10, 20 and 40 days after starting either treatment. The secondary out-comes were the healing rate, the partial or complete resolution of itching and burning, the rate of complications and adverse events, patients' quality of life and satisfaction at the same time points. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05616455
Study type Interventional
Source Treviso Regional Hospital
Contact
Status Completed
Phase Phase 4
Start date October 1, 2021
Completion date May 31, 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT06216223 - Laser Versus Surgery in Anal Diseases in Inflammatory Bowel Patients N/A
Not yet recruiting NCT05405634 - Microbiota in Chronic Anal Fissure and Its Association With Prognosis
Completed NCT05736926 - Anal Fissure Among Survivors of COVID-19 Virus Infection.
Enrolling by invitation NCT00980369 - The Importance of Lateral Internal Sphincterotomy Incision: Parallel or Vertical N/A
Completed NCT04173130 - Monocentric Feasibility Study for a New Medical Device for the Treatment of Anal Fissure With Botulinum Toxin N/A
Completed NCT03345511 - Ultrasound Guided Caudal Block for Benign Anal Surgery N/A
Completed NCT05341180 - Efficacy of Polyethylene Glycol vs Lactulose With Isabgol in Acute Fissure-in-Ano: PEGASIS Trial Phase 2/Phase 3
Completed NCT03528772 - Topical Minoxidil Versus Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure N/A
Active, not recruiting NCT04428697 - Sungurtekin Technique vs. Closed Lateral Internal Sphincterotomy Technique N/A
Terminated NCT02023047 - An Open Label Multi-Dose Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing Phase 1/Phase 2
Withdrawn NCT01920074 - Pharmacokinetic,Safety and Exploratory Efficacy of RECTIV® in Adolescents With Chronic Anal Fissure Phase 4
Recruiting NCT01039051 - Diet and Lifestyle Intervention Study in Postpartum Women in China Phase 2/Phase 3
Completed NCT00210444 - Efficacy Study of Dysport® in the Treatment of Anal Fissure. Phase 2
Completed NCT00827736 - Comparison of Treatment Success of Botox Injection in the Internal Sphincter Versus Isosorbidedinitrate Ointment in Patients With an Anal Fissure Phase 4
Withdrawn NCT02667535 - PK, PD and Safety Comparative Trial of Isosorbide Mononitrate Gel in Healthy Participants and With Anal Fissure Phase 1
Not yet recruiting NCT06049524 - Could Preoperative Assessment of Physical and Psychological Status Help Predict Pain After Anorectal Surgery?
Not yet recruiting NCT05709717 - Regenerative Therapy With Autologous Stromal Vascular Fraction Derived Mesenchymal Stem Cells and Platelet-rich Plasma to Treat Complex Perianal Diseases
Completed NCT05038605 - Topical vs Oral Metronidazole After Benign Anorectal Surgery N/A
Not yet recruiting NCT03780998 - Effects of Sodium Pentaborat Based Gel on Perianal Benign Diseases
Completed NCT03426449 - Posterolateral Versus Lateral Internal Anal Sphincterotomy for Chronic Anal Fissure N/A