Characterizing Iodine-124 Evuzumitide (AT-01) in Systemic Amyloidosis

Status Recruiting

Clinical Trial Summary

This is a single center prospective study evaluating 124I-evuzumitide in patients with systemic amyloidosis. The purpose of this study is to 1)identify and characterize the distribution and uptake of 124I-evuzumitide in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) and 2) Correlate the uptake with the structure and function of different organs, including the heart. To achieve these goals, eligible patients will undergo primarily hybrid positron emission tomography and magnetic resonance imaging (PET/MRI). In a subgroup of patients who are unable to undergo PET/MR, computed tomography will be used instead of MRI (i.e. PET/CT). In a subgroup of patients, repeat imaging with the same modality will be done at a interval of 6-12 months. Clinically available data (demographics, phenotype, imaging, laboratory) will also be collected to characterize the disease in each patient.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05758493
Study type	Interventional
Source	Oregon Health and Science University
Contact	Ahmad Masri, MD
Phone	503-418-1964
Email	masria@ohsu.edu
Status	Recruiting
Phase	Phase 2
Start date	January 10, 2023
Completion date	July 10, 2024

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