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Clinical Trial Summary

This is a single center prospective study evaluating 124I-evuzumitide in patients with systemic amyloidosis. The purpose of this study is to 1)identify and characterize the distribution and uptake of 124I-evuzumitide in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) and 2) Correlate the uptake with the structure and function of different organs, including the heart. To achieve these goals, eligible patients will undergo primarily hybrid positron emission tomography and magnetic resonance imaging (PET/MRI). In a subgroup of patients who are unable to undergo PET/MR, computed tomography will be used instead of MRI (i.e. PET/CT). In a subgroup of patients, repeat imaging with the same modality will be done at a interval of 6-12 months. Clinically available data (demographics, phenotype, imaging, laboratory) will also be collected to characterize the disease in each patient.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05758493
Study type Interventional
Source Oregon Health and Science University
Contact Ahmad Masri, MD
Phone 503-418-1964
Email masria@ohsu.edu
Status Recruiting
Phase Phase 2
Start date January 10, 2023
Completion date July 10, 2024

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