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Effect of Radiotherapy on ATTR Cardiac Amyloidosis : a Proof of Concept Study

Amyloid Cardiomyopathy Clinical Trial

Official title:
Effect of Radiotherapy on ATTR Cardiac Amyloidosis : a Proof of Concept Study

Clinical Trial Summary

Cardiac amyloidosis is responsible for significant morbidity associated with heart failure, and carries a poor prognosis. Currently there are very limited treatment options for this condition. Radiotherapy has been used successfully to treat amyloidosis elsewhere in the body, however has not been tried in cardiac amyloidosis. Therefore this study aims to assess the effect of radiotherapy on cardiac amyloidosis, to evaluate whether it can successfully reduce the burden of amyloid deposits in the myocardium as assessed by 18F-Amyloid PET.

Clinical Trial Description

The intervention will involve administration of external beam radiotherapy (5 fractions of 2Gy) focused to the heart. Measurements of effect will be assessed at 12 weeks by: Amyloid PET Cardiac MRI with administration of gadolinium and ultrasound A blood venous sample (cardiac biomarkers) Quality of life assessments ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03397810
Study type Interventional
Source University Hospital, Geneva
Contact René Nkoulou, Dr.
Phone +41 22 37 27 196
Email rene.nkoulou@hcuge.ch
Status Recruiting
Phase N/A
Start date March 15, 2019
Completion date February 28, 2026
View Details
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