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Association Between Lifetime Physical Activity and Exercise and the Development of Wild-type Transthyretin Amyloid Cardiomyopathy

Amyloid Cardiomyopathy Clinical Trial

Official title:
Association Between Lifetime Physical Activity and Exercise and the Development of Wild-type Transthyretin Amyloid Cardiomyopathy

Clinical Trial Summary

The aim of this study is to investigate the association between increased lifetime physical activity and the development of wild-type transthyretin amyloid cardiomyopathy.

Clinical Trial Description

Transthyretin amyloidosis is considered to be the most common cause of cardiac amyloidosis, with an increasing diagnosis rate over the last decade. Though once considered to be a rare disease, recent data suggest it is underappreciated as a common cause of cardiac diseases and syndromes such as left ventricular hypertrophy, aortic stenosis, and heart failure with preserved ejection fraction, especially in the elderly. Wild-type transthyretin amyloidosis, which is associated with ageing, is currently considered to be the most frequent form of amyloidosis worldwide, and is dominated by cardiac symptoms. Other than male gender and advanced age, risk factors for the development of wild-type transthyretin amyloid cardiomyopathy (wtATTR-CM) are largely unknown. There is rising empirical observation that patients with wtATTR-CM frequently have a substantial history of athletic activity, which might contribute to the manifestation of the disease. This study aims to create evidence of a correlation between increased lifetime physical activity and the development of wtATTR-CM. Furthermore, we aim to explore the association between certain sport disciplines and disease development. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06261216
Study type Observational
Source Medical University of Graz
Contact Nicolas Verheyen, MD PhD
Phone 031638530173
Email nicolas.verheyen@medunigraz.at
Status Recruiting
Phase
Start date February 2024
Completion date February 2025
View Details
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