Obesity Clinical Trial
Official title:
Identification of Epigenetic Markers Common to Obesity and Alzheimer's Disease in Women - Pilot Study
The purpose of this study is to compare average methylation of epigenetic markers on genomic
DNA and some genes (APP, BACE, LRP, SorL1) involved in cerebral amyloid homeostasis:
- Of obese young adults and healthy young adults
- Of obese young adults and individuals affected by Alzheimer's disease (AD) having been
obese at young adult age (<50 years old) or individuals affected by Alzheimer's disease
(AD) having never been obese.
The secondary purpose is to determine if there is an association between the frequency of
these epigenetic markers and elements associated to the metabolic syndrome (lipidic and
glycemic analysis, leptinemia, inflammation markers) and clinical ones (visceral fat mass,
body mass index) in young adults.
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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