Alzheimer's Disease Clinical Trial
Official title:
Constructional Apraxia in Alzheimer's Disease (AD) and Lewy Body's Dementia (LBD)
Alzheimer's disease (AD) and Lewy body's dementia (LBD) are two frequent neurodegenerative
pathologies. They differ in their expression, their evolution but share same features which
make their diagnosis uneasy.
Constructional apraxia has been described in both disease.The underlying mechanisms have
been less studied and could be different in AD and LBD.
The definition of the constructional apraxia is purely descriptive and few models are
inconclusive.
It is admitted that drawing tasks involve visuo-perceptive and visuo-spatial abilities,
executive functions and working memory as well as purely "constructive" skills.
Regarding to different studies, visuo-perceptive abilities are more severely impaired in LBD
than in AD and are considered as an early onset sign of the disease.
Executive functions deficits are documented in AD and LDB and could contribute to the
drawing impairment.
It is possible to compensate the planning disorders in giving patient the best strategy to
use.
If drawing impairment persists, they should result of others mechanisms like
visuo-perception, visuo-spatial or constructive deficits.
The investigators suggest that giving the best planning strategy will help more AD patients
who are supposed to fail in raison of an executive impairment, than the LDB group who is
supposed to present visuo-perceptive deficits. An MRI will be proposed to study the cerebral
areas involved in constructional apraxia.
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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