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Clinical Trial Summary

The pathophysiology of AD is complex. In addition to amyloid plaques and neurofibrillary degeneration, there is a metabolic alteration of the energy pathways, oxidative phosphorylation and glycolysis, which are involved in brain function. Several authors have shown a series of early metabolic dysregulations via an increase in phosphorylation at the origin of neuronal death. Ultra-high field imaging (7T MRI) may allow, with its better spatial resolution and advanced imaging techniques, to shed light on the mechanisms of progression of Alzheimer's disease. A Magnetic Resonance Spectroscopy (MRS) examination can be coupled to brain MRI without additional risk for the patient. Multinuclear 1H-31P metabolic imaging is a promising tool that can provide information on the metabolic evolutionary profile of AD. Thus, we propose a longitudinal study in patients with early-stage AD on 7T MRI-MRS.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05939362
Study type Interventional
Source Poitiers University Hospital
Contact Adrien JULIAN, Dr
Phone 05.49.44.44.44
Email adrien.julian@chu-poitiers.fr
Status Recruiting
Phase N/A
Start date October 2, 2023
Completion date January 15, 2027

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