The Role of the Locus Coeruleus in Age-related Distractibility

Status Recruiting

Clinical Trial Summary

A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these declines are still largely unclear. The objective of this proposal is to investigate neural mechanisms of age-related attentional distractibility, focusing on the neural circuit initiated from the locus coeruleus (LC). In the current proposal, the investigators will test the hypothesis that the neural dysconnectivity of LC with the salience network (SN) drives failures of ignoring distractors in older adults. The investigators will examine how LC-SN connectivity is associated with selective attention performance, and how improved LC-SN connectivity through a cognitive training program may lead to improved attentional performance.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05574634
Study type	Interventional
Source	Virginia Polytechnic Institute and State University
Contact	Tae-Ho Lee, PhD
Phone	540-231-6174
Email	taehol@vt.edu
Status	Recruiting
Phase	N/A
Start date	April 11, 2023
Completion date	June 30, 2027

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