Comparison of the Effect of Online Physical Exercise and Computerized Cognitive Stimulation in Patients With Alzheimer's Disease

Alzheimer Disease Clinical Trial

Official title:

Comparison of the Effect of Online Physical Exercise and Computerized Cognitive Stimulation in Patients With Alzheimer's Disease During the Covid-19 Pandemic

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04842734
• Other study ID #: 25.03.2021/37
• Status: Completed
• Phase: N/A
• Start date: April 27, 2021
• Est. completion date: December 25, 2021

Study information

• Verified date: July 2022
• Source: Yeditepe University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Our aim has been determined to investigate the effect of physical exercise alone and in combination with cognitive exercise, on cognitive, physical function and quality of life in individuals with Alzheimer's Disease during the Covid-19 pandemic period.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: December 25, 2021
• Est. primary completion date: July 23, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• = 65 years and older
• Diagnosed with AD according to DSM-IV diagnostic criteria by a neurologist,
• MOCA = 13
• Clinical Dementia Rating Scale < 2
• Having sufficient wireless support or telephone connection where the person lives
• Who gave consent to participate in the study
• No history of any neurological or orthopedic injury that could prevent participation in the study and affect functional mobility.

Exclusion Criteria:

• Geriatric Depression Scale score > 11
• Various mobility restrictions, musculoskeletal disorders, (wheelchair use, etc.)
• Clinically significant aphasia (must be able to understand the therapist's commands)
• Significant visual or sensory impairment
• MoCA < 13
• Having a severe musculoskeletal disorder
• Having paralysis
• Impaired balance
• The presence of severe lung and heart disease

Related Conditions & MeSH terms

• Alzheimer Disease
• Computerized Cognitive Stimulation
• COVID-19
• Covid-19 Pandemic
• Online Physical Exercise
• Telerehabilitation

Intervention

Other:
• Physical exercise
SPEP are planned for 12 weeks, 2 times a week, once a day, 60 minutes / 1 hour
• Physical exercise and computerized cognitive training
SPEP are planned for 12 weeks, 2 times a week, once a day, 60 minutes / 1 hour. The CCSP is planned for 12 weeks, minimum 3 to maximum 5 days a week, approximately 10 minutes, for a total of 36-60 sessions

Locations

Country	Name	City	State
Turkey	Yeditepe University	Istanbul	Eyalet/Yerleske

Sponsors (1)

Lead Sponsor	Collaborator
Yeditepe University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Alzheimer's Disease Related Quality of Life Scale	This scale evaluates health-related quality of life in individuals with AD. The scale includes 40 questions in total and examines 5 quality of life domains (A-Social Interaction, B-Self Awareness, C-Affect and Mood, D- Enjoying Activities, E-Interaction with the Environment).	24 weeks
Primary	Montreal Cognitive Assessment Scale	MOCA is a short cognitive assessment method developed to detect particularly mild stages of cognitive impairment.	24 weeks
Primary	Berg Balance Scale	Berg Balance Scale measures static and dynamic balance in elderly individuals.	24 weeks
Primary	Time up and Go Test	TUG test evaluates fall risk, mobility and physical performance in the elderly	24 weeks
Primary	Sit to Stand Test	Sit-to-stand test will be performed on an armless chair with a height of 46 cm to determine the physical fitness level of elderly individuals	24 weeks
Primary	Arm Curl Test	The Arm Curl test is one of the subtests of the Senior fitness test and it is performed to evaluate upper extremity muscle strength	24 weeks
Secondary	Katz Activities of Daily Living Scale	Katz ADLs consist of six questions that include information about bathing, dressing, toilet, movement, excretion, and feeding activities.	24 weeks
Secondary	Lawton Instrumental Activities of Daily Living Scale	Lawton IADL scale consists of 8 items and a single subscale. In addition, it consists of eight questions about using the phone, preparing meals, shopping, doing daily household chores, washing clothes, getting on the transportation vehicle, taking medicines and money management	24 weeks
Secondary	Geriatric Depression Scale (Short Form)	The GDS Short Form (GDS-15) is a 15-item scale that is used for the diagnosis of depression in elderly individuals	24 weeks