Using Technology to Support Care Partners for Persons With Alzheimer's Disease: Tele-STELLA

Alzheimer Disease Clinical Trial

— Tele-STELLA  

Official title:

Using Technology to Support Care Partners for Persons With Alzheimer's Disease: Tele-STELLA

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04627662
• Other study ID #: STUDY00022288
• Status: Recruiting
• Phase: N/A
• Start date: May 14, 2021
• Est. completion date: January 15, 2026

Study information

• Verified date: June 2023
• Source: Oregon Health and Science University
• Contact: Allison Lindauer, PhD
• Phone: 503-494-6976
• Email: lindauer[@]ohsu.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to test a revised psychoeducational intervention to help Care Partners for family members with dementia understand and reduce the distressing behaviors that come with progressive dementia. Tele-STELLA (Support via TEchnology: Living and Learning with Advancing Alzheimer's disease and related dementias) is a multicomponent videoconference-based intervention designed to facilitate effective management of behavioral and psychological symptoms common to the later stages of dementia. In the Tele-STELLA intervention, professionals ("Guides") meet with family members ("Care Partners") who care for persons with dementia. Working together, the Care Partners and Guides identify strategies to address upsetting behaviors. The goal of this intervention is to reduce upsetting behaviors and, thus, Care Partner burden.

Description:

Providing care for a family member with Alzheimer's disease and related dementias (ADRD, aka, "dementia") is both rewarding and risky. Care Partners exposed to chronic stress, often over years, are susceptible to physical and psychological ailments. Effective interventions that reduce Care Partner burden and health risks are available, but various factors impede participation, including distance, cost, behavioral symptoms of dementia, stigma and social anxiety. Recognizing the need to reduce barriers to access, scientists have turned to Internet-based interventions. Recent research indicates that multi-component, technology-facilitated interventions which allow Care Partner engagement with health professionals are effective and favored by Care Partners. However, a minority of telehealth-based interventions allow for health professional engagement and, of these, only a handful provide real-time interaction. Further, Hopwood et al. concluded that, despite the fact that family needs vary across ADRD stages, the interventions reviewed were not targeted to specific stages of dementia.

To address the needs of families living with dementia, the investigators have completed two pilot studies using Internet-based Care Partner interventions. These studies tested the feasibility and consumer acceptability of the evidence-based, STAR-C intervention, the precursor to Tele-STELLA, when delivered via telehealth. Qualitative data revealed the telehealth intervention was acceptable to Care Partners and preferred over a potential in-home intervention. The investigators found that burden was reduced, but depression was not. This may be because the interaction with the Guide formally ended after Session 8, leaving Care Partners with a sense of isolation, as this one commented: "I went through withdrawals… I wanted to call her (the Guide)-who can I turn to?" The prototype interventions did not include meaningful opportunities for Care Partners to interact with each other post-intervention. Care Partners felt their support vanished and did not like "the fact that it was over." Care Partners advised that future interventions should include both one-to-one sessions and one-to-multiple sessions.

Based on the qualitative and quantitative data from the pilot work, Tele-STELLA was designed to address the specific needs of families living with moderate to severe dementia. Tele-STELLA is a multi-component, tailored intervention that begins with one-to-one sessions with each Care Partner and Guide, then links Care Partners to each other in a meaningful way to sustain support post intervention. Tele-STELLA is designed for families living in the later stages of dementia, where behavioral symptoms are more prominent and distressing.

The ultimate goal of this study is to diminish the frequency of behavioral symptoms that persons with dementia experience, and Care Partner reactivity to these symptoms. Based on Kales et al. framework, behavioral symptoms arise from unmet needs, overburdened Care Partners and environmental factors, all within the context of cultural background and beliefs. Behavioral symptoms are bidirectional in that the person with dementia's behaviors affects the Care Partner's behaviors and vice versa. The investigators hypothesize that addressing these factors will reduce behavioral symptom frequency, and, in turn, Care Partner reactivity to them, resulting in reduced Care Partner burden, depression and grief.

Tele-STELLA allows all study activities to be done in Care Partners' homes, using videoconferencing, email and phones. This includes assessments of burden and depression using electronic versions of classic measures. No visits to university sites are needed.

The purpose of this study is to test a revised psychoeducational intervention to help Care Partners for family members with dementia understand and reduce the distressing behaviors that come with progressive dementia. Tele-STELLA (Support via TEchnology: Living and Learning with Advancing Alzheimer's disease and related dementias) is a multicomponent videoconference-based intervention designed to facilitate effective management of behavioral and psychological symptoms common to the later stages of dementia. In the Tele-STELLA intervention, professionals ("Guides") meet with family members ("Care Partners") who care for persons with dementia. Working together, the Care Partners and Guides identify strategies to address upsetting behaviors. The goal of this intervention is to reduce upsetting behaviors and, thus, Care Partner burden.

The specific aims of this study are:

Aim 1. Establish the feasibility and acceptability of Tele-STELLA

1. Assess the feasibility of implementing Tele-STELLA with a national participant pool, including participants from multiple Alzheimer's Disease Research Centers.

2. Assess feasibility and acceptability of the Constellation component of Tele-STELLA.

3. Assess user acceptability of Tele-STELLA and fidelity to the intervention protocol. Refine and optimize Tele-STELLA, as needed, based on above findings.

Aim 2. Establish the efficacy of Tele-STELLA in reducing the frequency of behavioral and psychological symptoms of dementia (BPSD) and Care Partner reactivity to the symptoms.

H1: Participants who completed the Tele-STELLA intervention will report a significant reduction in the frequency of BPSD and Care Partner reactivity to the BPSD.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 300
• Est. completion date: January 15, 2026
• Est. primary completion date: January 15, 2026
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Care Recipient Inclusion Criteria:

• Diagnosis of ADRD, moderate to late stages as defined by family member (Box 1)

• Exhibits 2 or more behaviors listed on RMBPC that are bothersome to the Care Partner and occur 3 or more times/week at study enrollment

• Family member of Care Partner (this can be a relative, spouse or close kin that is considered family)

Care Recipient Exclusion Criteria:

• Dementia not related to ADRD

• Unable to leave Care Partner during Tele-STELLA sessions

• Early stage dementia, as defined by family member

Care Partner Inclusion Criteria:

• Adult caring for family member with ADRD

• Provides care for at least 4 hours/week

• Age of 18 years or older

• Speaks and understands English to be able to participate in intervention

• Owns a telephone (smartphone, cell phone or landline)

• Has mailing address to receive computer and study materials

• Provides informed consent to participate in the Research

Care Partner Exclusion Criteria:

• Unable to find activity for care recipient during Tele-STELLA sessions to allow Care Partner to work privately with Guide and other Care Partners.

• Completed similar telehealth intervention within the last year

• Hearing and/or vision problems severe enough to prevent participation

• Unwilling or unable to adequately follow study instructions and participate in study procedures

Related Conditions & MeSH terms

• Alzheimer Disease
• Caregiver Burden
• Caregiver Burnout
• Dementia
• Family Members

Intervention

Behavioral:
• Tele-STELLA
Tele-STELLA (Support via TEchnology: Living and Learning with Advancing Alzheimer's disease and related dementias) is a multicomponent videoconference-based intervention designed to facilitate effective management of behavioral and psychological symptoms common to the later stages of dementia.

Locations

Country	Name	City	State
United States	Oregon Health and Science University, Layton Aging and Alzheimer's Disease Center	Portland	Oregon

Sponsors (1)

Lead Sponsor	Collaborator
Oregon Health and Science University

Country where clinical trial is conducted

United States, 

References & Publications (1)

Lindauer A, Messecar D, McKenzie G, Gibson A, Wharton W, Bianchi A, Tarter R, Tadesse R, Boardman C, Golonka O, Gothard S, Dodge HH. The Tele-STELLA protocol: Telehealth-based support for families living with later-stage Alzheimer's disease. J Adv Nurs. 2021 Oct;77(10):4254-4267. doi: 10.1111/jan.14980. Epub 2021 Jul 20. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Revised Memory and Behavior Problems Checklist	Care partner difficulty in managing behavioral symptoms of dementia. 24-item caregiver report measure, 5-point Likert scale, higher scores mean greater behavioral problems.	12 Months
Secondary	Marwit Meuser Caregiver Grief Index-Short Form	Care partner pre-death grief. 18-item caregiver report measure. 5-point Likert scale. Higher scores mean greater grief.	12 Months
Secondary	Quality of Life in Alzheimer's Disease	Quality of life of care partners and care recipients	12 Months
Secondary	Center for Epidemiological Studies Depression Scale	Care partner depression. 20-item caregiver report measure. 4-point Likert scale. Higher scores mean greater depression.	12 Months
Secondary	Out of pocket costs	Weekly survey of costs	12 months
Secondary	Health care use survey	Weekly survey of health care use	12 months
Secondary	4 item Zarit Burden Interview	Care partner burden. 4-item caregiver report measure, 5-point Likert scale, higher scores mean greater burden.	12 Months
Secondary	Ten Item Personality Inventory	Assesses introversion/extraversion	6 months
Secondary	Computer Self-Efficacy and Computer Anxiety Survey	Assesses comfort with computers	6 months