Alzheimer Disease Clinical Trial
Official title:
Evaluation of the Effect of Probiotic Supplementation on Cognitive, Emotional and Related Status on Alzheimer's Dementia Patients
The present studies demonstrated that pro-inflammation, systemic oxidative stress and dysfunction in the brain-gut microbiota axis were involved in Alzheimer's disease (AD) pathogenesis. These results implied the decreased regulation of inflammation-associated risk and microbiota in AD patients could provide the novel strategies for combating the disease. This study was designed to assess the addition of Wismemo in treatment of cholinesterase inhibitors (such as donepezil, rivastigmine, galantamine) in the AD patients.
Previously studies have shown some probiotics could improve stress-related diseases such as
anxiety, autism, depression and schizophrenia might be through regulating brain-gut
microbiota axis, pro-inflammation and oxidative stress. Although recent clinical study
indicated that mix-probiotics (containing Lactobacillus acidophilus, Lactobacillus casei,
Bifidobacteria bifidum and Lactobacillus fermentum) consumption could improve the cognitive
function of dementia patients.
In this clinical study, whether Genmont specific strain probiotics could improve the clinical
syndromes and delay worsens in Alzheimer's dementia patients with regular treatment were
clarified. A Randomized, double-blind, placebo-controlled clinical trial would be carried
out. AD's patients with regular treatment are additive consumption multi-strain probiotic
supplement (Wismemo). Half of participants will receive Wismeno and regular treatment in
combination, while the other half will receive placebo and regular treatment in combination.
To evaluate of the effect of probiotic supplementation on cognitive, emotional and related
status on Alzheimer's dementia patients.
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