SNIFF - 3-Week Aptar CPS Device

Status Not yet recruiting

Clinical Trial Summary

The SNIFF 3-Week Aptar Device study will involve using a device to administer insulin or placebo through each participant's nose or intra-nasally. Insulin is a hormone that is produced in the body. It works by lowering levels of glucose (sugar) in the blood. This study is measuring how much insulin the device delivers. In addition, this study will look at the effects of insulin or placebo administered intra-nasally using an intranasal delivery device on memory, blood, and cerebrospinal fluid (CSF).

Clinical Trial Description

The proposed study will examine whether an intranasal delivery device can be used by adults with preclinical Alzheimer's disease (cognitively normal but with abnormal brain levels of the hallmark peptide Aβ) to reliably deliver insulin or placebo four times daily over a 4 week period. We will also examine effects of treatment on cognition, CSF biomarkers, and cerebral perfusion. If successful, information gained from the study will inform the design of future Phase III trials of intranasal insulin. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05006599
Study type	Interventional
Source	Wake Forest University Health Sciences
Contact	Deborah Dahl, RN
Phone	336-713-3432
Email	ddahl@wakehealth.edu
Status	Not yet recruiting
Phase	Phase 2
Start date	May 2025
Completion date	May 2031

View Details

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