Alzheimer Disease, Early Onset Clinical Trial
Official title:
Donepezil Use Versus Non-drug Approach in Treatment of Newly Diagnosed Alzheimer's Disease : a Multicentric, Randomized, Open Study : the CHOLINE-2 Study
Donepezil, as well as the other symptomatic drugs of Alzheimer's disease, is not any more reimbursed by the French healthcare system, due to a controversy about its efficiency. French health authorities currently preconize a non-rug approach based on cognitive remediation or stimulation. The aim of this study is to compare the efficiency of the 2 approaches (non-drug versus donepezil) on the symptoms of Alzheimer's disease after 6 months of treatment.
Randomized multicentric open-label study, comparison of 2 therapeutic strategies. 2 arms: - Standard of care, non-drug approach: following the recommendations of the Alzheimer's disease care by the Frenchh Health Authority. The care is cognitive, psychic, functional or social and centered on the patient and his environment. This care is best carried out by the memory consultations participating in this study and having extensive experience in the care of Alzheimer patients. It is usually based in particular on the prescription of cognitive stimulation sessions by a speech therapist and a mobile Alzheimer specialist team at home for cognitive remediation sessions. - Donepezil group: Management similar to the previous arm plus addition of Donepezil 5 mg per os once a day for one month and then 10 mg per os once a day until the 6th month. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT03625401 -
Efficacy and Safety of AD-35 in Treatment of Subjects With Mild to Moderate Alzheimer's Disease
|
Phase 2 | |
| Recruiting |
NCT05983575 -
A Pivotal Study of LIPUS-Brain in Patients With Early Alzheimer's Disease
|
Phase 3 | |
| Completed |
NCT05989087 -
The Resting-state EEG Gamma Oscillations in Alzheimer's Disease
|
||
| Recruiting |
NCT06080659 -
Network-based biOmarker Discovery of Neurodegenerative Diseases Using Multimodal Connectivity
|
N/A | |
| Not yet recruiting |
NCT06099587 -
MIMA Pilot Study: MIcrostructure of the Medial Temporal Lobe in Early Alzheimer's Disease
|
N/A | |
| Not yet recruiting |
NCT05604183 -
Hyperspectral Retinal Observations for the Cross-sectional Detection of Alzheimer's Disease
|
N/A | |
| Withdrawn |
NCT03514875 -
Effects of Mitochondrial-targeted Antioxidant on Mild Cognitive Impairment (MCI) Patients
|
N/A | |
| Recruiting |
NCT06203106 -
NYSCF Scientific Discovery Biobank
|
||
| Completed |
NCT03706885 -
Efavirenz for Patients With Alzheimer's Disease
|
Phase 1 | |
| Active, not recruiting |
NCT03661034 -
Study of Tolerability, Safety and Efficacy of Sensory Stimulation at Multiple Dose Levels to Improve Brain Function (Etude Study)
|
N/A | |
| Not yet recruiting |
NCT05006599 -
SNIFF - 3-Week Aptar CPS Device
|
Phase 2 | |
| Recruiting |
NCT02740634 -
Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study
|
N/A | |
| Active, not recruiting |
NCT03069391 -
The Interactive Physical and Cognitive Exercise System
|
N/A | |
| Recruiting |
NCT04701957 -
The Ketogenic Diet for Alzheimer's Disease
|
N/A | |
| Recruiting |
NCT06268886 -
Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease
|
Phase 2 | |
| Recruiting |
NCT04100889 -
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Alzheimer's Disease
|
||
| Recruiting |
NCT04656860 -
Juice Plus Supplement Clinical Trial
|
N/A | |
| Recruiting |
NCT05315895 -
The Dampness Syndrome of Chinese Medicine Cohort Study
|
||
| Recruiting |
NCT04916964 -
Adapted Home-based Exercise Program "T&E" (Test-and-Exercise) in Persons With Alzheimer's Disease (HOPE Trial)
|
N/A | |
| Recruiting |
NCT04804618 -
Proteomics Study of Mild Cognitive Impairment and Alzheimer's Disease
|