Alveolar Ridge Resorption After Extraction Clinical Trial
Official title:
Alveolar Ridge Preservation With Polycaprolactone Scaffold for Implant Site Development
It has been shown through research that alveolar ridges (Part of jaw bone holding teeth) tend
to lose width and height after extraction of teeth. Lost in height and width of the ridge can
cause problems in the restoration of missing teeth with bridges and implants. Hence, this
study is proposed to assess the use of polycaprolactone (PCL) scaffolds for alveolar ridge
preservation following extraction of teeth in humans.
20 patients will be divided into 2 groups. In one group, patients will have a PCL scaffold
placed into the socket after extraction. In other group, no scaffold will be placed. After a
healing period of 6 months, changes in width and height from baseline is measured for both
groups. A bone biopsy is also taken at this time from both groups. Hardness of bone,
histologic (microscopic) features of cells, percentage of living bone, radiographic density
of alveolar ridge and mechanical properties of the bone biopsy are then assessed.
This study will attempt to show that a resorbable (can be removed by body) material like a
PCL scaffold can be used to maintain physical dimensions of the alveolar ridge after
extraction and will not interfere with osseointegration (fusion with bone). It will avoid the
necessity for additional corrective surgeries for patients when alveolar ridges presented
with inadequate width and height for placement of aesthetically pleasing and functionally
sound restorations. This would improve chances of success for the patient.
If the study successfully shows that the PCL scaffold can be accepted by the body with good
bone growth, uses for the PCL scaffold can be extended to other areas of clinical medicine
and dentistry.
The PCL scaffold to be used in this study is designed and developed by a local company
(Osteopore International Pte Ltd). With the success of this product, Singapore's standing as
a biomedical hub will be further enhanced.
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