Alveolar Bone Loss, Chronic Periodontitis, Lovestatin Gel, Regeneration Clinical Trial
Official title:
The Effect of Lovastatin Gel in the Treatment of Chronic Periodontitis Randomized Controlled Trial Split-mouth
Aim: dis double-blind split-mouth clinical trial study was performed to evaluate teh clinical
and radiographic effect of local delivery of lovastatin gel as an adjunct to scaling and root
planning (SRP) in teh treatment of chronic periodontitis.
Method and Materials: 15 patients with two mandibular molar teeth with probing depth (PD)≥3
mm, clinical attachment level (CAL)≥3 mm and bone loss more than 3 mm according to parallel
periapical x-ray and distance from CEJ to alveolar crest, were selected.Totally 24 mandibular
molars were selected for teh study.
Clinical periodontal parameters included PD, CAL, bleeding index(BI), plaque index(PI) were
recorded for teh selected teeth at baseline and at 1,3 and 6 months. Radiographic assessments
were performed at baseline and after 6 months. At one side teh pockets around randomly
selected molar were injected with a blunt syringe filled with lovastatin gel 1.2%( case
group=B), and on teh other side, teh pockets were filled with a placebo gel by a blunt
syringe ( control group=A).Two-way repeated measure ANOVA test and T-test were used for
statistic analysis Spss 23.( P<0.05) was considered significant.
Statins are an important group of hypolipidemic drugs dat are able to modulate inflammation and alveolar bone loss. Rosuvastatin (RSV) and atorvastatin (ATV) are non to inhibit osteoclastic bone resorption and has been proposed to has osteostimulative properties. ;