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Allergy clinical trials

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NCT ID: NCT02306473 Completed - Asthma Clinical Trials

The Leaky Lung Test

Start date: October 2015
Phase: Early Phase 1
Study type: Interventional

This is a clinical trial designed to test the hypothesis that measuring the absorption and excretion of inhaled mannitol will provide a clinically useful marker of airway epithelial permeability in asthma.

NCT ID: NCT02295969 Completed - Allergy Clinical Trials

Observational Study of Oralair® in Children 5-9 Years With Grass-pollen-induced Allergic Rhinitis With/Without Conjunctivitis

Start date: December 2014
Phase: N/A
Study type: Observational

Safety and tolerability of ORALAIR in children 5 to 9 years of age during the first 30 days of treatment.

NCT ID: NCT02293343 Completed - Allergy Clinical Trials

24 Hrs Histamine Profile in Healthy Persons and Patients With Food Intolerance

Start date: October 2014
Phase: N/A
Study type: Observational

Over 24 hrs serum and plasma samples were collected every 3 hrs. With this a day histamine profile was created. 15 healthy persons with 20 patients with a high level of IgE in serum and 20 patients with afflictions but no high IgE level were compared. Measurment of histamine in plasma, urine and stool were realized. In addition to that Diaminoxidase, TNF alpha and IgE Antibodies were measured.

NCT ID: NCT02264535 Completed - Allergy Clinical Trials

A Pilot Study for Ginkgolides Meglumine Injection Skin Testing.

Start date: June 2014
Phase: Phase 4
Study type: Interventional

This pilot study is designed to explore the optimal concentration and method of Ginkgolides Meglumine Injection skin testing and to evaluate the value of skin test in predicting any possible allergic reactions to Ginkgolides Meglumine Injection.

NCT ID: NCT02262065 Completed - Allergy Clinical Trials

Risk Factors for Enhanced Inflammation to Arthroplasty Wear Particles: Analysis of Cytokine Production and Polymorphisms

Start date: July 2012
Phase:
Study type: Observational

Assessment of cytokine polymorphisms in 100 patients with aseptic complications to arthroplasty as compared to 100 symptom-free arthroplasty patients. In selected patients additional in-vitro cytokine release assay with peripheral blood mononuclear cells (PBMC) stimulated with different wear particles.

NCT ID: NCT02255604 Completed - Allergy Clinical Trials

Effect of Intralymphatic Immunotherapy

Start date: August 2013
Phase: Phase 2
Study type: Interventional

The investigators want to investigate whether specific immunotherapy can be delivered directly into a lymph node. The investigators think that a direct introduction of allergen to the antigen presenting cells in the lymph node a give a strong immune response and that this can change the number of injections needed in allergen immunotherapy. The investigators do measurements of clinical effect and a variety of paraclinical test to see if the investigators can find af biomarker of successful specific immune therapy of grass allergy.

NCT ID: NCT02200692 Completed - Allergy Clinical Trials

Allergic Transfusion Reactions in Plasma Transfusion

Start date: June 2014
Phase:
Study type: Observational

Allergic transfusion reactions are a common complication of transfusion by blood components containing plasma. This study aims to investigate passive transfer of Immunoglobin E antibodies as a risk factor of allergic reactions to plasma transfusion by use of Solvent Detergent plasma.

NCT ID: NCT02180581 Completed - Allergy Clinical Trials

Effect of Probiotics in Reducing Infections and Allergies in Young Children Starting Daycare

ProbiComp
Start date: August 2014
Phase: N/A
Study type: Interventional

The aim of the intervention is to examine the effect of a combination of the two bacterial strains BB-12 and LGG, provided for 6 month, on the prevalence of infections and allergic manifestations in small children, and how a combination of BB-12 and LGG affects the immune system, gastrointestinal tract and the microbiota. Children are enrolled during 2 winter seasons.

NCT ID: NCT02168478 Completed - Allergy Clinical Trials

Neo-Synalar Modified 48 Hour Patch Test

Start date: June 2014
Phase: Phase 4
Study type: Interventional

A 48 hour patch test performed in healthy volunteers to determine the presensitization (pre-existing allergy) of Neo-Synalar (neomycin sulfate 0.5%(0.35% neomycin base), fluocinolone acetonide 0.025%) Cream . Subjects also receive a positive control (Sodium Lauryl Sulfate) and a negative control (Saline). The primary objective of this study is to determine if any subjects exhibit an allergic reaction which may be indicative of a pre-existing sensitization.

NCT ID: NCT02127801 Completed - Allergy Clinical Trials

Single Ascending-dose Study of the Efficacy, Safety, Tolerability, and Pharmacokinetics of REGN1908-1909 in Allergic, Adult Participants

Start date: October 31, 2014
Phase: Phase 1
Study type: Interventional

The purposes of this study are to assess the efficacy, safety and tolerability of a single dose of REGN1908-1909 in allergic adult participants, to collect information about how much REGN1908-1909 is in blood over time and to collect information about how the body reacts to REGN1908-1909.