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NCT01019291 Clinical Trial

Role of Indoor Pollutants on House Dust Mite Allergic Asthma

Allergic Asthma Clinical Trial

Official title:
Aldehyde and Nitrogen Dioxide at Homes: Measurement of the Exposure and Their Role on Allergic Asthma

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT01019291
Other study ID # 3965
Secondary ID
Status Withdrawn
Phase N/A
First received November 23, 2009
Last updated March 26, 2015

Study information
Verified date March 2015
Source University Hospital, Strasbourg, France
Contact n/a
Is FDA regulated No
Health authority France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
Study type Interventional

Clinical Trial Summary

It seems that the aldehydes and NO2, at the levels found indoor, could be the aggravating factors for an allergic response. However this effect has not been demonstrated. The investigators plan to study the effect of exposure to standard doses of these pollutants on the bronchial reactivity as measured by bronchial challenge tests with dust mite extract in volunteers asthmatic, allergic to house dust mite.

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 50 Years
Eligibility Inclusion criteria:

- M/F 18-50 years of age

- History of intermittent HDM allergic asthma-FEV1 > 80%

- Non smokers or smokers with smoking < 10 PY

Exclusion criteria:

- Persistent asthma and FEV1<80%

- Allergic to pets and pets at home

Study Design

Allocation: Randomized, Masking: Double Blind (Subject, Investigator)

Related Conditions & MeSH terms

Intervention

Other:
• Formaldehyde and NO2 (Exposure to indoor pollutants)
Exposure to indoor pollutants (Formaldehyde and NO2) in a randomized way, followed by bronchial challenge test with house dust mite extract.
• Placebo (Exposure to indoor pollutants)
Exposure to indoor pollutants (placebo) in a randomized way, followed by bronchial challenge test with house dust mite extract.

Locations
Country Name City State
France Unité de Pneumologie, d'Allergologie et de Pathologie Respiratoire de l'Environnement, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg Strasbourg

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Strasbourg, France

Country where clinical trial is conducted

France, 

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