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Diclofenac as a KMO Inhibitor — DKMOI  

Alcohol Use Disorder Clinical Trial

Official title:
Proof of Concept: Diclofenac as a KMO Inhibitor in Individuals With Alcohol Use Disorder

Clinical Trial Summary

This mechanistic, proof of concept laboratory study will test the pharmacological properties of diclofenac in individuals with AUD. Participants will complete two sessions in which they will receive a single dose of diclofenac (100 mg) or matched placebo in a randomized and double blind fashion. The primary aim is to assess whether this dose of diclofenac, vs. placebo, increases circulating levels of kynurenic acid. This finding would provide evidence that diclofenac (100 mg) inhibits the kynurenine 3-monooxygenase enzyme.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06029296
Study type Interventional
Source University of Maryland, Baltimore
Contact Brian Brandler, MA
Phone 410-402-6425
Email bbrandler@som.umaryland.edu
Status Not yet recruiting
Phase Early Phase 1
Start date June 2024
Completion date December 2024
View Details
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