Does Oxytocin Alter Tolerance to or Motivation for Alcohol

Status Terminated

Clinical Trial Summary

This pilot study will seek evidence that oxytocin, compared to placebo, reverses tolerance and alcohol seeking in humans.

Clinical Trial Description

This pilot study will seek evidence that intranasal oxytocin reverses tolerance and alcohol seeking in humans by employing state-of-the-art computer-assisted intravenous alcohol administration. Two separate experiments will be run. In the first, tolerance will be assessed using sensitive tests of subjective response and cognitive function during an intravenous infusion that maintains a steady breath and therefore brain exposure to alcohol. In the second, an intravenous alcohol self-administration paradigm that requires increasing effort for each additional infusion will be used to assess change in motivation for alcohol. Demonstrating that oxytocin (compared to placebo) worsens test performances in alcohol-dependent individuals and/or reduces the compulsive drive to self-administer alcohol would be strong evidence for its potential to treat alcohol use disorders. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05312008
Study type	Interventional
Source	Indiana University
Contact
Status	Terminated
Phase	Phase 2
Start date	January 16, 2022
Completion date	December 21, 2023

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