Portrayal of Hospital Alcohol Detoxification in France

Alcohol Use Disorder Clinical Trial

— Alcostop  

Official title:

Portrayal of Hospital Alcohol Detoxifications and Factors Associated With Longer or Ulterior Hospitalizations in France From 2011 to 2020

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04973202
• Other study ID #: RECHMPL21_0456
• Status: Completed
• Start date: May 1, 2021
• Est. completion date: August 30, 2021

Study information

• Verified date: October 2021
• Source: University Hospital, Montpellier
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Even if hospital alcohol detoxifications are frequent in France, their caracteristicscharacteristics remain unknown. The investigators aim to describe the clinical and paraclinical caracteristicscharacteristics of their patients, their length and geographical repartition, etc… The investigators also aim to evaluate factors associated with longer stays or ulterior re-hospitalization for the same reason. Finally, The investigators aim to compare the stays by facility type.

Description:

Context:

In France, the consequences of excessive alcohol use are one of the primary reasons for hospitalization. When stopping the substance, patients with an alcohol use disorder can suffer from a potentially fatal alcohol withdrawal syndrome. To mitigate these risks, a withdrawal under medical supervision is possible, either in an outpatient setting or in hospital, where the detoxification can be programmed or imposed. In the course of an alcohol dependent patient's life, re-drinking is not exceptional and the patient may undergo several withdrawals during his or her life.

Psychiatric pathologies, especially anxiety and depression, are more frequent in these patients than in the rest of the population, just as can be somatic pathologies.e. Withdrawal accidents, represented by comital seizures and delirium tremens, can be critical.

In hospital detoxifications, studies do not show any benefit in continuing the stay beyond 10 days, except in the case of somatic or psychiatric complication. However, little information is available on the average length of stay for hospital alcohol detoxification.

Although alcohol dependence issues are very frequent and the resulting withdrawals are relatively common and associated with numerous comorbidities, little data exists at a national level in France.

The aim of this study is to describe these hospital detoxifications: course, duration, frequency and clinical and paraclinical characteristics of the patients. We also wish to analyze which characteristics are associated with longer stays or re-hospitalization and to compare the care according to the facility type.

Objectives:

Main:

• To describe the clinical, paraclinical, and stay characteristics of hospital alcohol detoxification in France

Secondary:

• To describe the regional distribution of hospital alcohol detoxification

• To evaluate whether certain clinical characteristics are associated with a longer hospital stays

• To evaluate whether certain clinical characteristics are associated with subsequent re-hospitalization for the same reason

• To compare the characteristics of patient stays by type of facility

Methods:

In this descriptive observational study using pre-existing data accessed via the PMSI (Programme de Médicalisation des Systèmes d'Information), we will use all hospital stays from 2011 to 2020 for alcohol detoxification in France, both in public and private settings.

For each hospital stay will be collected the length, the antecedents of hospital alcohol detoxification, clinical and psychiatric comorbidities, withdrawals complication, alcohol use complication, further examinations.

We will describe the stays using median and quartiles for continuous variables and number and percentage for dichotomous variables. For secondary objectives, we will use a multivariate linear regression model if the length of stay is normal, an ordinal regression model otherwise. The characteristics of the stays will be compared regarding the type of facility using univariate comparative tests: Chi² or Fisher for dichotomous variables and Student or Mann-Whitney for continuous variables.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50000
• Est. completion date: August 30, 2021
• Est. primary completion date: August 30, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion criteria:

Inclusion criteria:

• French patients of at least 18 years old

• Inpatients of a public or private care facility for alcohol detoxification

• From 01/01/2011 to 12/31/2020

• In a medical or psychiatric hospital

Exclusion criteria:

• age < 18 years

Related Conditions & MeSH terms

• Addiction
• Alcohol Use Disorder
• Alcohol Withdrawal Syndrome
• Alcoholism
• Substance Withdrawal Syndrome

Intervention

Other:
• Stay for alcohol detoxification
Stay for alcohol detoxification : routine care.

Locations

Country	Name	City	State
France	Uhmontpellier	Montpellier

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Montpellier

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	description of age	Age at admission (in years), calculated by the difference of the year of admission and the year of birth through the PMSI.	day 1 (At hospital inclusion)
Primary	description of sex	Sex collected through the PMSI.	day 1 (At hospital inclusion)
Secondary	description of geographic code	Sex collected through the PMSI.	day 1 (At hospital inclusion)
Secondary	description of CMU-C	CMU-C (universal complementary health insurance, collected through the PMSI.	day 1 (At hospital inclusion)
Secondary	Length of stay	Length of stay (in days), calculated by the difference between the discharge date and the entry date, collected through the PMSI.	During the stay (day 1 - day 15)
Secondary	Care establishment	Name and type of the care establishment, collected through the PMSI.	During the stay (day 1 - day 15)
Secondary	Number of previous hospital detoxification stays in the studied period	Number of previous hospital detoxification stays in the studied period, collected through the PMSI.	During the stay (day 1 - day 15)
Secondary	Psychiatric comorbidities	Psychiatric comorbidities (Major depression episode, anxiety, psychotic trouble, personality diseases), collected through the PMSI.	During the stay (day 1 - day 15)
Secondary	Withdrawal complication	Withdrawal complications (delirium tremens, comitial seizures), collected through the PMSI.	During the stay (day 1 - day 15)
Secondary	Further examination	Further examination (biology, imagery, etc…), collected through the PMSI.	During the stay (day 1 - day 15)
Secondary	Re-hospitalization for same reason	For each patient, and each stay, we will evaluate if the patient had an ulterior re-hospitalization for alcohol withdrawal. Collected through the PMSI.	day 1